Document Detail

Is airways hyperreactivity selective or non-selective?
MedLine Citation:
PMID:  8368166     Owner:  NLM     Status:  MEDLINE    
Airways hyperresponsiveness has often been termed "nonspecific" on account of close correlations between responses to histamine and methacholine. This relationship, however, does not apply to stimuli, such as exercise, hyperventilation, sulphur dioxide, and distilled water. We have shown that allergen causes a greater and more prolonged increase in responses to bradykinin than to methacholine adding support to the notion that airways hyperresponsiveness is a selective pathophysiologic abnormality.
R Djukanović
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Agents and actions. Supplements     Volume:  43     ISSN:  0379-0363     ISO Abbreviation:  Agents Actions Suppl.     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-07     Completed Date:  1993-10-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7801014     Medline TA:  Agents Actions Suppl     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
University of Southampton General Hospital, UK.
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MeSH Terms
Allergens / diagnostic use
Asthma / etiology
Bronchial Hyperreactivity / immunology*
Bronchoconstrictor Agents / diagnostic use
Histamine / diagnostic use
Methacholine Chloride / diagnostic use
Reg. No./Substance:
0/Allergens; 0/Bronchoconstrictor Agents; 51-45-6/Histamine; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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