| The airway vasculature: recent advances and clinical implications. | |
| | |
MedLine Citation:
|
PMID: 19401490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is increasingly recognised that the airway circulation plays an important role in airway diseases, either through a change in blood flow or through microvascular leakage. Most of the information available regarding the anatomy and physiology of bronchial blood flow and its regulation has necessarily derived from animal studies. However, there have recently been important advances in understanding airway blood flow in airway disease in humans through the development of non-invasive methods and in the quantification of microvascular leakage using plasma markers. These studies have shown that bronchial blood flow is increased in patients with asthma but not in those with chronic obstructive pulmonary disease, confirming previous pathology investigations. Changes in bronchial blood flow may in part reflect the generation of new vascular vessels, a process known as "angiogenesis" which is caused by airway inflammation. Angiogenesis and the resulting plasma leak affect airway physiology, drug clearance and its bioavailability. This review discusses the anatomy, physiology and regulation of bronchial blood flow in the normal and diseased lung, In addition, it analyses the effect of current medical treatment and discusses the potential use of new anti-angiogenesis medications. The development of non-invasive assessment of bronchial blood flow and the study of angiogenesis have provided a tool to investigate airway physiology in vivo; these advances will contribute to a better understanding of inflammatory airway diseases as well as the implication of these findings to management. |
| | |
Authors:
|
P Paredi; P J Barnes |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Thorax Volume: 64 ISSN: 1468-3296 ISO Abbreviation: Thorax Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-29 Completed Date: 2009-06-18 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
|
Languages: eng Pagination: 444-50 Citation Subset: IM |
Affiliation:
|
National Heart and Lung Institute, London, UK. p.paredi@ic.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Adrenergic beta-Agonists / therapeutic use Angiogenesis Inhibitors / therapeutic use Bronchi / anatomy & histology, blood supply*, physiopathology Bronchial Arteries / anatomy & histology, physiology Humans Lung Diseases / drug therapy, pathology, physiopathology* Microcirculation / physiology Neovascularization, Physiologic / physiology Pulmonary Circulation / physiology Receptors, TIE / antagonists & inhibitors Vascular Endothelial Growth Factor A / antagonists & inhibitors Veins / anatomy & histology, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Angiogenesis Inhibitors; 0/Vascular Endothelial Growth Factor A; EC 2.7.10.1/Receptors, TIE |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Familial idiopathic pulmonary fibrosis in association with bone marrow hypoplasia and hepatic nodula...
Next Document: Retinoid induction of alveolar regeneration: from mice to man?