Document Detail

The aging musculoskeletal system and obesity-related considerations with exercise.
MedLine Citation:
PMID:  22440321     Owner:  NLM     Status:  MEDLINE    
Advancing age and adiposity contribute to musculoskeletal degenerative diseases and the development of sarcopenic obesity. The etiology of muscle loss is multifactorial, and includes inflammation, oxidative stress and hormonal changes, and is worsened by activity avoidance due to fear of pain. The risk for mobility disability and functional impairment rises with severity of obesity in the older adult. Performance measures of walking distance, walking speed, chair rise, stair climb, body transfers and ability to navigate obstacles on a course are adversely affected in this population, and this reflects decline in daily physical functioning. Exercise training is an ideal intervention to counteract the effects of aging and obesity. The 18 randomized controlled trials of exercise studies with or without diet components reviewed here indicate that 3-18 month programs that included aerobic and strengthening exercise (2-3 days per week) with caloric restriction (typically 750 kcal deficit/day), induced the greatest change in functional performance measures compared with exercise or diet alone. Importantly, resistance exercise attenuates muscle mass loss with the interventions. These interventions can also combat factors that invoke sarcopenia, including inflammation, oxidative stress and insulin resistance. Therefore, regular multimodal exercise coupled with diet appears to be very effective for counteracting sarocpenic obesity and improving mobility and function in the older, obese adult.
Heather K Vincent; Sara N Raiser; Kevin R Vincent
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-03-15
Journal Detail:
Title:  Ageing research reviews     Volume:  11     ISSN:  1872-9649     ISO Abbreviation:  Ageing Res. Rev.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101128963     Medline TA:  Ageing Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  361-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Orthopaedics and Rehabilitation, Division of Research, Interdisciplinary Center for Musculoskeletal Training and Research, University of Florida, Gainesville, FL 32611, USA.
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MeSH Terms
Aging / physiology*
Exercise / physiology*
Motor Activity / physiology
Muscle Strength / physiology*
Musculoskeletal System
Obesity / physiopathology*,  prevention & control
Osteoporosis / physiopathology*,  prevention & control
Randomized Controlled Trials as Topic / methods
Sarcopenia / physiopathology,  prevention & control
Weight Loss / physiology
Grant Support

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