Document Detail

The aging brain, neuroinflammatory signaling and sleep-wake regulation.
MedLine Citation:
PMID:  21072987     Owner:  NLM     Status:  MEDLINE    
Tissues and organs change over time, regulated by intrinsic (genetic) determinants and environmental (and microenvironmental) adaptation. Brain changes during lifetime are especially critical, as the brain is the effector of cognition and the vast majority of neurons live throughout the life of the individual. In addition, brain aging mechanisms are especially critical for disease vulnerability, given the aging-related prevalence of pathologies that include neurodegenerative diseases. In this context, the present contribution concisely highlights data yielded by recent trends of research on the normal aging brain, and specifically: the occurrence of synaptic changes (rather than neuronal loss) and the altered regulation of adult neurogenesis (which represents a novel exciting field of knowledge); the development of a low-grade chronic inflammatory state which primes glial cells and may lead to changes in intercellular crosstalk, thus playing a potential role in the brain susceptibility to neurodegeneration; changes occurring in state-dependent behavior, sleep and wake, which are products of global brain functioning and underlie consciousness and cognitive performance; changes in the biological clock, the hypothalamic suprachiasmatic nucleus, which regulates sleep-wake alternation and other endogenous rhythms. Altogether, the present synopsis of recent studies at the molecular, cellular, and functional levels emphasizes the idea that the normal aging brain should be viewed as an example of adaptation and plasticity rather than as an obligatory decline.
Giuseppe Bertini; Valeria Colavito; Cristina Tognoli; Paul F Seke Etet; Marina Bentivoglio
Related Documents :
12165477 - Cholinergic modulation of experience-dependent plasticity in human auditory cortex.
20053917 - Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance ...
12386697 - Suitability of containers from different sources as breeding sites of aedes aegypti (l....
24045617 - Patterned neuronal networks using nanodiamonds and the effect of varying nanodiamond pr...
674257 - Method for the rapid determination of norepinephrine, dopamine, and serotonin in the sa...
4537207 - Specialized membrane junctions between neurons in the vertebrate cerebellar cortex.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  115     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-13     Revised Date:  2012-04-05    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Section of Anatomy and Histology, Department of Neuroscience, University of Verona.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / pathology*,  physiology
Brain / anatomy & histology,  pathology*,  physiology
Circadian Rhythm / physiology
Inflammation / pathology*,  physiopathology
Neuronal Plasticity / physiology
Neurons / pathology*,  physiology
Signal Transduction / physiology*
Sleep / physiology*
Wakefulness / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Contacts between mast cells and dendritic cells in the human skin.
Next Document:  Recent advances in molecular diagnostics of colorectal cancer by genomic arrays: proposal for a proc...