| The aggressiveness of urinary tract urothelial carcinoma increases with the severity of chronic kidney disease. | |
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MedLine Citation:
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PMID: 19549259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess, in a retrospective cohort, urinary tract urothelial carcinoma (UT-UC) in patients with various stages of chronic kidney disease (CKD) and their clinicopathological features, as patients with end-stage renal disease (ESRD) have a higher incidence of UT-UC, but the relationship between early stages of CKD and characteristics of UT-UC are less well known. PATIENTS AND METHODS: The study included 267 patients with pathologically confirmed UT-UC from January 1994 to December 2006; all had a physical examination (blood pressure), and measurements of laboratory data (serum creatinine, serum haemoglobin) and pathological data. The glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease equation. Patients were divided into three groups by individual GFR (mL/min), i.e. >60 (no/mild CKD), 30-60 (CKD stage 3) and <30 (CKD stage 4/5). RESULTS: The CKD stages included 81 (30.3%) patients with none/mild CKD, 121 (45.3%) with CKD stage 3 and 65 (24.3%) with CKD stage 4/5. There was a significant and parallel increase in the frequency of UT-UC as CKD severity increased from none/mild CKD to stage 3 (11% vs 55%), and from CKD stage 3 to 4/5 (55% vs 71%; P < 0.05). Pathologically, the frequency of high-grade and high T stage UT-UC in patients with CKD stage 3 (90% and 35%, respectively) and CKD stage 4/5 (91% and 29%, respectively) were significantly greater than in the group with none/mild CKD (P < 0.001). Advanced age and more distant metastasis were independent risk factors for patient survival. CONCLUSION: The aggressiveness of UT-UC increased with the severity of CKD, and this might have important clinical consequences. |
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Authors:
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Peir-Haur Hung; Cheng-Huang Shen; Yen-Ling Chiu; Ing-Ching Jong; Pei-Chun Chiang; Chang-Te Lin; Kuan-Yu Hung; Tun-Jun Tsai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-22 |
Journal Detail:
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Title: BJU international Volume: 104 ISSN: 1464-410X ISO Abbreviation: BJU Int. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: England |
Other Details:
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Languages: eng Pagination: 1471-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Chia-yi Christian Hospital, Chia-yi, Taiwan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chronic Disease Epidemiologic Methods Female Glomerular Filtration Rate Humans Kidney Diseases / complications, mortality, pathology* Male Middle Aged Urologic Neoplasms / complications, mortality, pathology* Urothelium / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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