Document Detail


The aggregation and inheritance of damaged proteins determines cell fate during mitosis.
MedLine Citation:
PMID:  24553116     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent evidence suggests that proliferating cells polarize damaged proteins during mitosis to protect one cell from aging, and that the structural conformation of damaged proteins mediates their toxicity. We report that the growth, resistance to stress, and differentiation characteristics of a cancer cell line (PC12) with an inducible Huntingtin (Htt) fused to enhanced green fluorescent protein (GFP) are dependent on the conformation of Htt. Cell progeny containing inclusion bodies have a longer cell cycle and increased resistance to stress than those with diffuse Htt. Using live imaging, we demonstrate that asymmetric division resulting from a cell containing a single inclusion body produces sister cells with different fates. The cell that receives the inclusion body has decreased proliferation and increased differentiation compared with its sister cell without Htt. This is the first report that reveals a functional consequence of the asymmetric division of damaged proteins in mammalian cells, and we suggest that this is a result of inclusion body-induced proteasome impairment.
Authors:
Mary Rose Bufalino; Derek van der Kooy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-11
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  13     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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