| The agglutinin response to whole-cell and acellular pertussis vaccines is Bordetella pertussis--strain dependent. | |
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MedLine Citation:
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PMID: 1415040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the significance of the Bordetella pertussis strain used as the antigen in the agglutinin assay for the evaluation of pertussis vaccines. DESIGN: Randomized, double-blind study. SETTING: Health maintenance organization clinics, primary care clinic at a referral hospital, and private practices in Los Angeles County, California. PARTICIPANTS: Forty healthy infants. SELECTION PROCEDURES: Convenience sample. INTERVENTIONS: Twenty infants received whole-cell pertussis-component diphtheria-tetanus-pertussis vaccine (DTP), and 70 infants received acellular pertussis-component diphtheria-tetanus-pertussis vaccine (APDT) at ages 2, 4, and 6 months. MEASUREMENTS: The agglutinin assay was performed using three separate B pertussis strain preparations: (1) strains 130 and 138 in equal quantities, the constituents of the DTP vaccine, (2) strain 460, and (3) strain Tohama, the constituent of the APDT vaccine. RESULTS: The agglutinin titers were highly strain dependent; in both groups of vaccinees at both ages the Tohama values were highest, followed by strain 460 and then strains 130/138. The vaccine groups had comparable titers at age 2 months regardless of the assay antigen used. However, at age 7 months, after three immunizations, the DTP group geometric mean titer was more than 10 times greater than that of the ADPT group using strains 130/138, but only 2.6 times higher using strain 460 and almost equivalent using Tohama strain. CONCLUSION: Vaccine group agglutinin value comparisons strongly depend on assay antigens used. |
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Authors:
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D A Blumberg; E Pineda; J D Cherry; A Caruso; J V Scott |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 146 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-10-29 Completed Date: 1992-10-29 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1148-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, UCLA School of Medicine 90024-1752. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agglutination Tests
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methods,
standards* Antibody Formation Antigens, Bacterial / immunology* Bordetella pertussis / classification*, immunology Humans Infant Los Angeles Pertussis Vaccine / classification, immunology, therapeutic use* Serotyping* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Pertussis Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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