Document Detail

The ageing pineal gland and its physiological consequences.
MedLine Citation:
PMID:  1586370     Owner:  NLM     Status:  MEDLINE    
Melatonin, the chief hormone of the pineal gland, is produced and secreted into the blood in a circadian manner with maximal production always occurring during the dark phase of the light:dark cycle. Whereas the 24h rhythm of melatonin production is very robust in young animals including humans, the cycle deteriorates during ageing. The rhythm of melatonin can be substantially preserved during ageing by restricting the food intake of experimental animals; this same treatment increases the life span of the animals. The exogenous administration of melatonin to non-food restricted animals also reportedly increases their survival. Moreover, melatonin has been shown to have immunoenhancing effects and oncostatic properties. The implication of these studies is that melatonin may have both direct and indirect beneficial effects in delaying ageing processes or it may retard the development of processes (e.g., immunodeficiency and tumor growth) which contribute to a reduced life span.
R J Reiter
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  14     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-12     Completed Date:  1992-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
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MeSH Terms
Aging / physiology*
Circadian Rhythm
Melatonin / physiology*
Pineal Gland / physiology*
Reg. No./Substance:

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