| The aged epidermal permeability barrier: basis for functional abnormalities. | |
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MedLine Citation:
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PMID: 11913735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aged epidermis develops an abnormality in permeability barrier homeostasis, which is accentuated further in photoaged skin. The biochemical basis is a global reduction in stratum corneum lipids and profound abnormality in cholesterol synthesis. Various cytokine/growth factor signaling pathways are abnormal in aged skin, particularly in the interleukin-1 family. Barrier repair therapy can be effective in restoring normal function if a cholesterol-dominant mixture of the three key physiologic lipids, including ceramides and free fatty acids, is emphasized. |
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Authors:
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Peter M Elias; Ruby Ghadially |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in geriatric medicine Volume: 18 ISSN: 0749-0690 ISO Abbreviation: Clin. Geriatr. Med. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-03-26 Completed Date: 2002-05-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8603766 Medline TA: Clin Geriatr Med Country: United States |
Other Details:
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Languages: eng Pagination: 103-20, vii Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of California, San Francisco, USA. eliaspm@itsa.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / physiology CCAAT-Enhancer-Binding Proteins / physiology Cell Membrane Permeability* DNA-Binding Proteins / physiology Epidermal Growth Factor / physiology Epidermis / physiology* Humans Interleukin-1 / physiology Skin Aging / physiology Sterol Regulatory Element Binding Protein 1 Transcription Factors / physiology |
| Chemical | |
Reg. No./Substance:
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0/CCAAT-Enhancer-Binding Proteins; 0/DNA-Binding Proteins; 0/Interleukin-1; 0/SREBF1 protein, human; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors; 62229-50-9/Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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