Document Detail


Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?
MedLine Citation:
PMID:  21724748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: and aims Cross-sectional studies suggest that obstructive lung disease (OLD) and smoking affect lean mass and mobility. A study was undertaken to investigate whether OLD and smoking accelerate the ageing-related decline in lean mass and physical functioning.
METHODS: 260 patients with OLD (mean±SD forced expiratory volume in 1 s (FEV1) 63±18% predicted), 157 smoking controls (FEV(1) 95±16% predicted), 866 former-smoking controls (FEV1 100±16% predicted) and 891 never-smoking controls (FEV1 104±17% predicted) participating in the Health, Aging and Body Composition (ABC) Study were studied. At baseline the mean age was 74±3 years and participants reported no functional limitations. Baseline and 7-year longitudinal data of body composition (by dual-energy x-ray absorptiometry), muscle strength (by hand and leg dynamometry) and Short Physical Performance Battery (SPPB) were investigated.
RESULTS: Compared with never-smoking controls, patients with OLD and smoking controls had a significantly lower weight, fat mass, lean mass and bone mineral content (BMC) at baseline (p<0.05). While the loss of weight, fat mass, lean mass and strength was comparable between patients with OLD and never-smoking controls, the SPPB declined 0.12 points/year faster in men with OLD (p=0.01) and BMC declined 4 g/year faster in women with OLD (p=0.02). In smoking controls only lean mass declined 0.1 kg/year faster in women (p=0.03) and BMC 8 g/year faster in men (p=0.02) compared with never-smoking controls.
CONCLUSIONS: Initially well-functioning older adults with mild-to-moderate OLD and smokers without OLD have a comparable compromised baseline profile of body composition and physical functioning, while 7-year longitudinal trajectories are to a large extent comparable to those observed in never-smokers without OLD. This suggests a common insult earlier in life related to smoking.
Authors:
Bram van den Borst; Annemarie Koster; Binbing Yu; Harry R Gosker; Bernd Meibohm; Douglas C Bauer; Stephen B Kritchevsky; Yongmei Liu; Anne B Newman; Tamara B Harris; Annemie M W J Schols
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-07-01
Journal Detail:
Title:  Thorax     Volume:  66     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2011-12-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  961-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / physiology*
Anthropometry / methods
Body Composition / physiology*
Case-Control Studies
Female
Forced Expiratory Volume / physiology
Humans
Inflammation Mediators / blood
Longitudinal Studies
Lung Diseases, Obstructive / etiology,  physiopathology*
Male
Motor Activity / physiology*
Muscle Strength / physiology
Smoking / adverse effects,  physiopathology*
Vital Capacity / physiology
Weight Loss / physiology
Grant Support
ID/Acronym/Agency:
K24 AR051895/AR/NIAMS NIH HHS; N01 AG062101/AG/NIA NIH HHS; N01 AG062103/AG/NIA NIH HHS; N01 AG062106/AG/NIA NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; R01-HL-74104/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators
Comments/Corrections
Comment In:
Thorax. 2011 Nov;66(11):933-5   [PMID:  21813620 ]

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