Document Detail


The aetiology of severe anaemia among antenatal patients of the Port Moresby General Hospital.
MedLine Citation:
PMID:  16454396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between October 1998 and September 2000, 111 consecutive pregnant patients admitted to the Port Moresby General Hospital antenatal ward with a haemoglobin level of 6 g/dl or less were studied. The main causes of the severe anaemia were as follows: iron deficiency on its own or in combination with another factor 66%--iron deficiency on its own 43% and combined folate and iron deficiency 23%--and folate deficiency 18%. Malaria was a contributory factor in 13 patients (12%). A combination of blood film, bone marrow study, serum assays of ferritin, folate and vitamin B12, and mean corpuscular volume (MCV) was used to determine the cause of the anaemia. Ferritin levels on their own poorly correlated with the presence of iron in the bone marrow. A low MCV correlated well with iron deficiency anaemia while a high MCV was associated with folic acid deficiency. It would seem therefore that while a bone marrow study is mandatory to reach a definitive diagnosis of severe anaemia, MCV, in conjunction with the red cell morphology on blood film, would be a good marker for iron and folic acid deficiency anaemia, especially as we do not have serum assays readily available for folate, ferritin and vitamin B12 in Papua New Guinea.
Authors:
A B Amoa; Evelyn Lavu; Udayan Ray; Mathias Sapuri; Grace Kariwiga; Shirley Heywood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Papua and New Guinea medical journal     Volume:  46     ISSN:  0031-1480     ISO Abbreviation:  P N G Med J     Publication Date:    2003 Sep-Dec
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376417     Medline TA:  P N G Med J     Country:  Papua New Guinea    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
Affiliation:
Port Moresby General Hospital, Papua New Guinea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / diagnosis,  etiology*
Anemia, Iron-Deficiency / complications,  diagnosis*
Anemia, Megaloblastic / complications,  diagnosis
Bone Marrow Examination
Erythrocyte Indices
Female
Ferritins / blood
Folic Acid Deficiency / complications,  diagnosis*
Hemosiderin / analysis
Humans
Jaundice / etiology
Malaria / complications,  diagnosis
Pregnancy
Pregnancy Complications, Hematologic / diagnosis,  etiology*
Prospective Studies
Splenomegaly / etiology
Chemical
Reg. No./Substance:
9007-73-2/Ferritins; 9011-92-1/Hemosiderin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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