| The adverse prognostic significance of the metabolic syndrome with and without hypertension in patients who underwent complete coronary revascularization. | |
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MedLine Citation:
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PMID: 19381109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The metabolic syndrome is associated with high risk for long-term coronary artery disease mortality. However, few studies have examined the prognostic importance of the metabolic syndrome with and without hypertension. METHODS: The data of 1133 nondiabetic patients who underwent complete revascularization were analyzed. The patients were categorized by the presence of the metabolic syndrome using the modified American Heart Association/National Heart, Lung, and Blood Institute statement and by the presence of hypertension. All patients were divided into four groups: neither the metabolic syndrome nor hypertension (group 1); the metabolic syndrome without hypertension (group 2); hypertension without the metabolic syndrome (group 3); and both the metabolic syndrome and hypertension (group 4). Cox proportional hazards were used in adjusted analyses for all-cause and cardiac mortality, as well as for the composite incidence of fatal and nonfatal stroke. RESULTS: The progress of 276 (24.4%) patients in group 1, 413 (36.5%) in group 2, 105 (9.3%) in group 3, and 339 (29.9%) in group 4 was analyzed. The mean follow-up was 10.4 +/- 3.4 years. Patients in group 4 had a higher risk of all-cause mortality (hazard ratio 1.78, P = 0.004). In addition, patients in groups 2 and 4 had a higher risk of cardiac mortality (group 2: hazard ratio 2.84, P = 0.04, group 4: hazard ratio 3.91, P = 0.001) and stroke (group 2: hazard ratio 2.46, P = 0.03, group 4: hazard ratio 2.09, P = 0.03). CONCLUSION: The metabolic syndrome both with and without hypertension is associated with increased risk of cardiac mortality and stroke incidence in patients who underwent complete coronary revascularization. |
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Authors:
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Takatoshi Kasai; Katsumi Miyauchi; Kan Kajimoto; Naozumi Kubota; Tomotaka Dohi; Takeshi Kurata; Atsushi Amano; Hiroyuki Daida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 27 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1017-24 Citation Subset: IM |
Affiliation:
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Departments of Cardiology, Juntendo University School of Medicine, Tokyo, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / methods* Cause of Death Coronary Artery Bypass / mortality* Coronary Artery Disease / complications*, mortality Disease Progression Female Follow-Up Studies Humans Hypertension / complications* Incidence Male Metabolic Syndrome X / complications*, mortality Middle Aged Prognosis Proportional Hazards Models Stroke / epidemiology Survival Rate Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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