Document Detail

The adverse prognostic significance of the metabolic syndrome with and without hypertension in patients who underwent complete coronary revascularization.
MedLine Citation:
PMID:  19381109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The metabolic syndrome is associated with high risk for long-term coronary artery disease mortality. However, few studies have examined the prognostic importance of the metabolic syndrome with and without hypertension. METHODS: The data of 1133 nondiabetic patients who underwent complete revascularization were analyzed. The patients were categorized by the presence of the metabolic syndrome using the modified American Heart Association/National Heart, Lung, and Blood Institute statement and by the presence of hypertension. All patients were divided into four groups: neither the metabolic syndrome nor hypertension (group 1); the metabolic syndrome without hypertension (group 2); hypertension without the metabolic syndrome (group 3); and both the metabolic syndrome and hypertension (group 4). Cox proportional hazards were used in adjusted analyses for all-cause and cardiac mortality, as well as for the composite incidence of fatal and nonfatal stroke. RESULTS: The progress of 276 (24.4%) patients in group 1, 413 (36.5%) in group 2, 105 (9.3%) in group 3, and 339 (29.9%) in group 4 was analyzed. The mean follow-up was 10.4 +/- 3.4 years. Patients in group 4 had a higher risk of all-cause mortality (hazard ratio 1.78, P = 0.004). In addition, patients in groups 2 and 4 had a higher risk of cardiac mortality (group 2: hazard ratio 2.84, P = 0.04, group 4: hazard ratio 3.91, P = 0.001) and stroke (group 2: hazard ratio 2.46, P = 0.03, group 4: hazard ratio 2.09, P = 0.03). CONCLUSION: The metabolic syndrome both with and without hypertension is associated with increased risk of cardiac mortality and stroke incidence in patients who underwent complete coronary revascularization.
Takatoshi Kasai; Katsumi Miyauchi; Kan Kajimoto; Naozumi Kubota; Tomotaka Dohi; Takeshi Kurata; Atsushi Amano; Hiroyuki Daida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  27     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1017-24     Citation Subset:  IM    
Departments of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / methods*
Cause of Death
Coronary Artery Bypass / mortality*
Coronary Artery Disease / complications*,  mortality
Disease Progression
Follow-Up Studies
Hypertension / complications*
Metabolic Syndrome X / complications*,  mortality
Middle Aged
Proportional Hazards Models
Stroke / epidemiology
Survival Rate
Time Factors
Treatment Outcome

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