Document Detail

The adverse pial arteriolar and axonal consequences of traumatic brain injury complicated by hypoxia and their therapeutic modulation with hypothermia in rat.
MedLine Citation:
PMID:  19904286     Owner:  NLM     Status:  MEDLINE    
This study examined the effect of posttraumatic hypoxia on cerebral vascular responsivity and axonal damage, while also exploring hypothermia's potential to attenuate these responses. Rats were subjected to impact acceleration injury (IAI) and equipped with cranial windows to assess vascular reactivity to topical acetylcholine, with postmortem analyses using antibodies to amyloid precursor protein to assess axonal damage. Animals were subjected to hypoxia alone, IAI and hypoxia, IAI and hypoxia before induction of moderate hypothermia (33 degrees C), IAI and hypoxia induced during hypothermic intervention, and IAI and hypoxia initiated after hypothermia. Hypoxia alone had no impact on vascular reactivity or axonal damage. Acceleration injury and posttraumatic hypoxia resulted in dramatic axonal damage and altered vascular reactivity. When IAI and hypoxia were followed by hypothermic intervention, no axonal or vascular protection ensued. However, when IAI was followed by hypoxia induced during hypothermia, axonal and vascular protection followed. When this same hypoxic insult followed the use of hypothermia, no benefit ensued. These studies show that early hypoxia and delayed hypoxia exert damaging axonal and vascular consequences. Although this damage is attenuated by hypothermia, this follows only when hypoxia occurs during hypothermia, with no benefit found if the hypoxic insult proceeds or follows hypothermia.
Guoyi Gao; Yasutaka Oda; Enoch P Wei; John T Povlishock
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Publication Detail:
Type:  Journal Article     Date:  2009-11-11
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  30     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-04-02     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  628-37     Citation Subset:  IM    
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.
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MeSH Terms
Acetylcholine / pharmacology
Arterioles / pathology
Axons / pathology*
Blood Pressure / physiology
Body Temperature / physiology
Brain Injuries / complications,  pathology*,  therapy*
Brain Stem / pathology
Carbon Dioxide / blood
Hypothermia, Induced*
Hypoxia, Brain / complications,  pathology*,  therapy*
Microcirculation / physiology
Oxygen / blood
Pia Mater / blood supply*,  pathology*
Rats, Sprague-Dawley
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 124-38-9/Carbon Dioxide; 51-84-3/Acetylcholine; 7782-44-7/Oxygen

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