| Cannabis; adverse effects from an oromucosal spray. | |
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MedLine Citation:
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PMID: 17703180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An oromucosal spray has been developed from the major components of marijuana (cannabis), including tetrahydrocannabinol (THC) and cannabidiol (CBD), in alcohol with a peppermint flavouring, designed to be administered as a spray under the tongue or on the buccal mucosa to relieve pain in multiple sclerosis. Although the available evidence indicates its efficacy in this respect, some patients develop oral burning sensation, stinging or white lesions, probably burns. OBJECTIVE: To investigate the oral side-effects of oromucosal cannabis spray in multiple sclerosis (MS) patients. DESIGN: A small open observational study. SUBJECTS AND METHODS: A series of nine patients with MS who had been using a marijuana oromucosal spray for at least four weeks, were asked to attend for oral examination. Patients were asked whether they had ever experienced symptoms (dryness; bad taste; stinging) associated with use of the spray. A standard oral examination was carried out using a dental light, and the presence of any mucosal lesions recorded. Where mucosal lesions were present, patients were advised to discontinue the spray and re-attend after four weeks for re-examination. For ethical reasons, biopsies were not undertaken at the first visit. RESULTS: Of nine patients invited to participate, eight attended. All admitted to a stinging sensation on using the oromucosal cannabis spray, and four had visible oral mucosal white lesions in the floor of the mouth. CONCLUSIONS: Although the white lesions observed were almost certainly burns, resolving or improving on discontinuation of use of the medication, the high alcohol concentration of the oromucosal cannabis spray raises concern in relation to chronic oral use. |
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Authors:
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C Scully |
Publication Detail:
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Type: Journal Article Date: 2007-08-17 |
Journal Detail:
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Title: British dental journal Volume: 203 ISSN: 1476-5373 ISO Abbreviation: Br Dent J Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2007-10-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513219 Medline TA: Br Dent J Country: England |
Other Details:
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Languages: eng Pagination: E12; discussion 336-7 Citation Subset: D; IM |
Affiliation:
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Department of Oral Medicine, UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD. c.scully@eastman.ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aerosols Aged Burns, Chemical / etiology* Cannabinoids / administration & dosage*, adverse effects* Cannabis / adverse effects* Female Humans Male Middle Aged Mouth Mucosa / drug effects* Multiple Sclerosis / drug therapy Pain / drug therapy Phytotherapy / adverse effects Plant Extracts / administration & dosage, adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Cannabinoids; 0/Plant Extracts; 0/tetrahydrocannabinol-cannabidiol combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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