Document Detail

The adverse effect of dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the secretion of prostaglandins and oxytocin in bovine cultured ovarian and endometrial cells.
MedLine Citation:
PMID:  19038325     Owner:  NLM     Status:  MEDLINE    
The influence of chlorinated hydrocarbon insecticide-dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the uterine prostaglandin (PGF2alpha and PGE2) and ovarian oxytocin (OT) secretion was investigated. Endometrial, granulosa and luteal cells from cows and heifers on 8-12 days of estrous cycle were treated (24-72h) with DDT, mixture or individual isomer (p,p'-, o,p'-) of DDE (0.1, 1 or 10ng/ml). The viability of cells and the concentrations of hormones in medium were determinted. Neither DDT nor DDE affected (P>0.05) the viability of cells, while they stimulated (P<0.05) PGF2alpha and reduced (P<0.001) PGE2 secretion from endometrial cells. Hence the ratio of PGF2alpha to PGE2 was markedly changed. Used pollutants also increased (P<0.05) OT secretion from ovarian cells. It is concluded that DDT and its metabolite impair PGF2alpha, PGE2 and OT secretion from uterus and ovary, respectively, and this way they can affect the course of estrous cycle in cattle.
Michal Wrobel; Jaroslaw Mlynarczuk; Jan Kotwica
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-07
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  27     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10-747 Olsztyn, Poland.
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MeSH Terms
Cell Survival / drug effects
DDT / toxicity*
Dichlorodiphenyl Dichloroethylene / toxicity*
Dinoprost / secretion
Dinoprostone / secretion
Endometrium / drug effects*,  secretion
Granulosa Cells / drug effects*,  secretion
Insecticides / toxicity*
Oxytocin / secretion*
Prostaglandins / secretion*
Reg. No./Substance:
0/Insecticides; 0/Prostaglandins; 363-24-6/Dinoprostone; 50-29-3/DDT; 50-56-6/Oxytocin; 551-11-1/Dinoprost; 72-55-9/Dichlorodiphenyl Dichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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