| The adverse effect of dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the secretion of prostaglandins and oxytocin in bovine cultured ovarian and endometrial cells. | |
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MedLine Citation:
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PMID: 19038325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of chlorinated hydrocarbon insecticide-dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the uterine prostaglandin (PGF2alpha and PGE2) and ovarian oxytocin (OT) secretion was investigated. Endometrial, granulosa and luteal cells from cows and heifers on 8-12 days of estrous cycle were treated (24-72h) with DDT, mixture or individual isomer (p,p'-, o,p'-) of DDE (0.1, 1 or 10ng/ml). The viability of cells and the concentrations of hormones in medium were determinted. Neither DDT nor DDE affected (P>0.05) the viability of cells, while they stimulated (P<0.05) PGF2alpha and reduced (P<0.001) PGE2 secretion from endometrial cells. Hence the ratio of PGF2alpha to PGE2 was markedly changed. Used pollutants also increased (P<0.05) OT secretion from ovarian cells. It is concluded that DDT and its metabolite impair PGF2alpha, PGE2 and OT secretion from uterus and ovary, respectively, and this way they can affect the course of estrous cycle in cattle. |
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Authors:
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Michal Wrobel; Jaroslaw Mlynarczuk; Jan Kotwica |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-07 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 27 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 72-8 Citation Subset: IM |
Affiliation:
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Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10-747 Olsztyn, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Cell Survival / drug effects DDT / toxicity* Dichlorodiphenyl Dichloroethylene / toxicity* Dinoprost / secretion Dinoprostone / secretion Endometrium / drug effects*, secretion Female Granulosa Cells / drug effects*, secretion Insecticides / toxicity* Oxytocin / secretion* Prostaglandins / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Insecticides; 0/Prostaglandins; 363-24-6/Dinoprostone; 50-29-3/DDT; 50-56-6/Oxytocin; 551-11-1/Dinoprost; 72-55-9/Dichlorodiphenyl Dichloroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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