| The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report. | |
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MedLine Citation:
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PMID: 1107499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of anticonvulsant medication to recipients of cadaver renal allografts appears to be associated with decreased allograft survival. The one-and two-year actuarial graft survival rates for 20 index grafts was significantly lower than for 92 control grafts. Since phenobarbital and diphenylhydantoin increase the metabolism of corticosteroids, it is proposed that renal allograft recipients receiving these anticonvulsants may have ineffective immunosuppression, leading to a higher incidence of graft failure. |
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Authors:
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S J Wassner; A J Pennisi; M H Malekzadeh; R N Fine |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 88 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1976 Jan |
Date Detail:
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Created Date: 1976-03-15 Completed Date: 1976-03-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 134-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticonvulsants / adverse effects*, therapeutic use Cadaver Child Child, Preschool Epilepsy / drug therapy Ethosuximide / adverse effects Humans Kidney Transplantation Phenobarbital / adverse effects Phenytoin / adverse effects Postoperative Complications / etiology* Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 50-06-6/Phenobarbital; 57-41-0/Phenytoin; 77-67-8/Ethosuximide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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