Document Detail


The adrenergic pharmacology of sympathetically-maintained pain.
MedLine Citation:
PMID:  1349919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors seek to highlight some of the recent advances in understanding the pharmacology and pathophysiology of sympathetically-maintained pain, and to develop alternate, and possibly more specific, diagnostic tests for this phenomenon. Mechanical hyperalgesia in sympathetically-maintained pain can be explained by central sensitization so that the activation of A-beta mechanoreceptors now causes pain. The sensitization of central pain-signaling neurons is dynamic and reversible. The authors propose that an ongoing input from peripheral nociceptive afferents is necessary to maintain central sensitization. This nociceptive input may be due to an alpha-adrenoceptor mediated excitatory action of sympathetic efferents on sensory nerves that is independent of neurovascular transmission.
Authors:
S N Raja; K D Davis; J N Campbell
Related Documents :
11352419 - Intercostal neuromas: a treatable cause of postoperative breast surgery pain.
20019619 - Role of cervical cordotomy and other neurolytic procedures in thoracic cancer pain.
19932939 - Pain around the ear in bell's palsy is referred pain of facial nerve origin: the role o...
12819899 - Increased sural nerve epineurial blood flow in human subjects with painful diabetic neu...
22918349 - Facial aesthetics and the assignment of personality traits before and after orthognathi...
756019 - Occipital neuralgia.
8845929 - Pain associated with spinal cord injury.
3886139 - Single-blind clinical trial comparing use of fentiazac and paracetamol in postendodonti...
14692389 - Patient's perception of pain on admission and discharge from the emergency department.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of reconstructive microsurgery     Volume:  8     ISSN:  0743-684X     ISO Abbreviation:  J Reconstr Microsurg     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2011-02-16    
Medline Journal Info:
Nlm Unique ID:  8502670     Medline TA:  J Reconstr Microsurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / therapeutic use*
Autonomic Nerve Block / methods*
Ganglia, Sympathetic / drug effects,  pathology,  physiopathology*
Humans
Hyperalgesia / diagnosis,  drug therapy,  etiology*,  physiopathology
Neurons, Afferent / drug effects,  physiology*
Neurons, Efferent / drug effects,  physiology*
Nociceptors / drug effects,  physiopathology*
Phentolamine / diagnostic use
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Serum dipeptidyl peptidase (DPP) IV activity in hamster buccal pouch carcinogenesis with 9,10-dimeth...
Next Document:  Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin.