Document Detail

The adrenergic pharmacology of sympathetically-maintained pain.
MedLine Citation:
PMID:  1349919     Owner:  NLM     Status:  MEDLINE    
The authors seek to highlight some of the recent advances in understanding the pharmacology and pathophysiology of sympathetically-maintained pain, and to develop alternate, and possibly more specific, diagnostic tests for this phenomenon. Mechanical hyperalgesia in sympathetically-maintained pain can be explained by central sensitization so that the activation of A-beta mechanoreceptors now causes pain. The sensitization of central pain-signaling neurons is dynamic and reversible. The authors propose that an ongoing input from peripheral nociceptive afferents is necessary to maintain central sensitization. This nociceptive input may be due to an alpha-adrenoceptor mediated excitatory action of sympathetic efferents on sensory nerves that is independent of neurovascular transmission.
S N Raja; K D Davis; J N Campbell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of reconstructive microsurgery     Volume:  8     ISSN:  0743-684X     ISO Abbreviation:  J Reconstr Microsurg     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2011-02-16    
Medline Journal Info:
Nlm Unique ID:  8502670     Medline TA:  J Reconstr Microsurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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MeSH Terms
Adrenergic alpha-Agonists / therapeutic use*
Autonomic Nerve Block / methods*
Ganglia, Sympathetic / drug effects,  pathology,  physiopathology*
Hyperalgesia / diagnosis,  drug therapy,  etiology*,  physiopathology
Neurons, Afferent / drug effects,  physiology*
Neurons, Efferent / drug effects,  physiology*
Nociceptors / drug effects,  physiopathology*
Phentolamine / diagnostic use
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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