| The adrenergic pharmacology of sympathetically-maintained pain. | |
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MedLine Citation:
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PMID: 1349919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors seek to highlight some of the recent advances in understanding the pharmacology and pathophysiology of sympathetically-maintained pain, and to develop alternate, and possibly more specific, diagnostic tests for this phenomenon. Mechanical hyperalgesia in sympathetically-maintained pain can be explained by central sensitization so that the activation of A-beta mechanoreceptors now causes pain. The sensitization of central pain-signaling neurons is dynamic and reversible. The authors propose that an ongoing input from peripheral nociceptive afferents is necessary to maintain central sensitization. This nociceptive input may be due to an alpha-adrenoceptor mediated excitatory action of sympathetic efferents on sensory nerves that is independent of neurovascular transmission. |
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Authors:
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S N Raja; K D Davis; J N Campbell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of reconstructive microsurgery Volume: 8 ISSN: 0743-684X ISO Abbreviation: J Reconstr Microsurg Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-06-16 Completed Date: 1992-06-16 Revised Date: 2011-02-16 |
Medline Journal Info:
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Nlm Unique ID: 8502670 Medline TA: J Reconstr Microsurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-9 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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therapeutic use* Autonomic Nerve Block / methods* Ganglia, Sympathetic / drug effects, pathology, physiopathology* Humans Hyperalgesia / diagnosis, drug therapy, etiology*, physiopathology Neurons, Afferent / drug effects, physiology* Neurons, Efferent / drug effects, physiology* Nociceptors / drug effects, physiopathology* Phentolamine / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 50-60-2/Phentolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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