Document Detail


The adrenergic alpha2 receptor and sexual incentive motivation in male rats.
MedLine Citation:
PMID:  16574206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present series of experiments was to determine whether drugs acting at the alpha2-adrenoceptor modify unconditioned sexual incentive motivation in the male rat. To that end a highly specific agonist, dexmedetomidine, a corresponding antagonist, atipamezole, and a less specific antagonist, yohimbine, were administered to groups of sexually inexperienced male rats. The subjects were tested in a large rectangular arena, where a sexually receptive female and an intact male were employed as incentives. The incentive animals were confined behind a wire mesh in opposite corners of the arena. The animals could see, hear and smell each other, but no sexual interaction was possible. Approach to the incentives constituted the measure of incentive motivation. In addition, the test provided data on ambulatory activity and general arousal. Dexmedetomidine, at a dose of 8 microg/kg, produced a slight reduction of sexual incentive motivation. Ambulatory activity and general arousal were also inhibited. Atipamezole, in doses of 0.1 and 0.3mg/kg enhanced the positive incentive properties of the receptive female. A high dose of 1mg/kg did not have any significant effect. Ambulatory activity was slightly reduced by the two larger doses of atipamezole. Yohimbine had a slight stimulatory effect on sexual incentive motivation at a dose (4 mg/kg) that also reduced ambulatory activity and general arousal. It is concluded that blockade of the adrenergic alpha2 receptor stimulates sexual incentive motivation in the male rat whereas stimulation of it has the opposite effect. At present it is not clear if these drug effects are caused by pre- or postsynaptic actions of the drugs, and the importance of secondary changes in other neurotransmitter systems remains unknown.
Authors:
Timo Viitamaa; Antti Haapalinna; Anders Agmo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  83     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-9     Citation Subset:  IM    
Affiliation:
Nonclinical R&D, Orion Pharma, Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / administration & dosage,  pharmacology
Adrenergic alpha-Antagonists / administration & dosage,  pharmacology
Animals
Copulation / drug effects,  physiology
Dexmedetomidine / administration & dosage,  pharmacology
Female
Imidazoles / administration & dosage,  pharmacology
Male
Motivation
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-2 / drug effects,  physiology*
Sexual Behavior, Animal / drug effects,  physiology*
Yohimbine / administration & dosage,  pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Imidazoles; 0/Receptors, Adrenergic, alpha-2; 104054-27-5/atipamezole; 113775-47-6/Dexmedetomidine; 146-48-5/Yohimbine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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