| The administration of oxytocin during early reperfusion, dose-dependently protects the isolated male rat heart against ischemia/reperfusion injury. | |
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MedLine Citation:
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PMID: 22406244 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In our previous study, the administration of oxytocin (OT) could precondition the heart against ischemia/reperfusion injury. In this study, to investigate the cardiac postconditioning effect of oxytocin, isolated rat hearts were mounted on a Langendorff perfusion apparatus. In all groups, the hearts underwent 30min of regional ischemia followed by 120min of reperfusion. In the ischemia/reperfusion (IR) group, ischemia and reperfusion was induced. In the ischemic postconditioning (Ipost) group, hearts underwent 6cycles of 10s reperfusion and 10s ischemia at the beginning of reperfusion. In the other groups (III-IX), OT was perfused 5min before the onset of reperfusion and continued for 25min with following doses (Molar): 10(-12), 5×10(-12), 8×10(-12), 10(-11), 2×10(-11), 5×10(-11), and 10(-10). The infarct size and coronary effluent levels of creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and malondialdehyde (MDA) were calculated at the end of reperfusion. The infarct size decreased considerably in Ipost group compared to IR group (P<0.05). Also, the infusion of oxytocin by doses of 8×10(-12)M, 10(-11)M and 2×10(-11)M dose-dependently reduced infarct size (P<0.05) significantly compared to the IR group. LDH level in coronary effluent was markedly decreased in Ipost group and treatment with oxytocin by doses of 8×10(-12)M, 10(-11)M, 2×10(-11)M and 5×10(-11)M (P<0.05) compared to IR group. Ipost, OT 2×10(-11)and 10(-11)M significantly decreased CK-MB level (P<0.05). Ipost, OT 8×10(-12), 10(-11) and 2×10(-11)M significantly decreased MDA level as compared to IR group. Our study shows that oxytocin dose-dependently exerts cardiac postconditioning. |
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Authors:
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Masood Aali Anvari; Alireza Imani; Mahdieh Faghihi; Seyed Morteza Karimian; Maryam Moghimian; Maryam Khansari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-3 |
Journal Detail:
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Title: European journal of pharmacology Volume: - ISSN: 1879-0712 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Department of physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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