| The administration of ciprofloxacin during continuous renal replacement therapy: pilot study. | |
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MedLine Citation:
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PMID: 19318919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous renal replacement therapy (CRRT) is a common technique in critically ill patients. However, there is no uniformity in the pharmacokinetics of ciprofloxacin (CPFX) used during CRRT. The aims of the present study were to estimate the pharmacokinetics of CPFX and to determine the appropriate administration of CPFX for critically ill patients undergoing CRRT. The pharmacokinetics of ciprofloxacin total clearance (CL(tot)) was calculated based on the creatinine clearance (CL(cre)), dialysate flow (QD), and ultrafiltrate flow (QF) as follows: CL(tot(L/h)) = (4.83 CL(cre(L/h)) + 6.41) + 0.92 (QD + Q(F(L/h))) based on in vitro study using CRRT circuit model. We administered CPFX to critically ill patients based on the CL(tot), which was 50 x CL(tot(L/h)) (mg/day). We confirmed that the CPFX concentrations reached higher than optimal concentrations, and infection was successfully controlled in these patients. |
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Authors:
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Mineji Hayakawa; Itaru Fujita; Ken Iseki; Satoshi Gando |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 55 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 243-5 Citation Subset: IM |
Affiliation:
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Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Hokkaido, Japan. mineji@dream.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Infective Agents / pharmacokinetics* Area Under Curve Ciprofloxacin / pharmacokinetics* Humans Male Pilot Projects Renal Replacement Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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