| The adjunctive use of metformin to treat or prevent atypical antipsychotic-induced weight gain: a review. | |
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MedLine Citation:
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PMID: 20859106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with schizophrenia have a greater incidence of being overweight or obese compared with the general population. Such individuals are often treated with second-generation (atypical) antipsychotics (SGAs), which are associated with weight gain, dyslipidemia, and other metabolic derangements. As a result, frequent monitoring of weight and other metabolic parameters is recommended. In addition, several pharmacologic strategies to help prevent or reduce SGA-induced weight gain have been proposed. Despite this, clinicians often struggle to manage obesity and metabolic issues in such patients. Metformin has attracted attention as a potential treatment option because it is thought to result in weight reduction and improved glycemic control in obese patients with and without type 2 diabetes mellitus. This article focuses on relevant pharmacologic aspects of metformin and reviews currently available evidence on the use of metformin as an augmentation agent for the treatment or prevention of SGA-induced weight gain. |
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Authors:
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Ahsan Y Khan; Matthew Macaluso; Robert J McHale; Megan M Dahmen; Kathrine Girrens; Faryal Ali |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of psychiatric practice Volume: 16 ISSN: 1538-1145 ISO Abbreviation: J Psychiatr Pract Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901141 Medline TA: J Psychiatr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 289-96 Citation Subset: IM |
Affiliation:
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University of Kansas School of Medicine-Wichita †Via Christi Regional Medical Center, Wichita, KS 67214, USA. akhan@kumc.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00816907 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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administration & dosage,
adverse effects* Blood Glucose / drug effects Body Weight / drug effects Humans Hypoglycemic Agents / therapeutic use* Metformin / therapeutic use* Obesity / chemically induced, drug therapy Overweight / chemically induced*, drug therapy* Schizophrenia / drug therapy* Treatment Outcome Weight Loss / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Blood Glucose; 0/Hypoglycemic Agents; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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