Document Detail


 Correlation of adipose tissue with liver histology in Asian Indian patients with nonalcoholic fatty liver disease (NAFLD).
MedLine Citation:
PMID:  22700629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is sparse literature on the association of adipose tissue with liver histology in patients with nonalcoholic fatty liver disease (NAFLD).
AIM: To study the correlation of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) with liver histology in Indian patients with NAFLD.
MATERIAL AND METHODS: A single slice CT scan at the level of L4-L5 vertebrae was done to assess the abdominal VAT and SAT volumes in 21 patients with histological diagnosis of NAFLD. Adult treatment panel III criteria with modified abnormal waist were used to define metabolic syndrome (MS). Histological grading was done according to the NAFLD activity score (NAS).
RESULTS: Twenty-one patients with NAFLD [13 males, median age: 35 years, median BMI: 25.97 kg/m(2)] were included prospectively. Even though overweight/obese patients had severe liver disease, there was no difference in the volume of VAT adjusted for BMI between 6 (28.5%) lean and 15 (71.5%) overweight/obese patients. Patients with NASH and borderline NASH were older, obese with higher VAT and SAT volumes than no-NASH group. SAT volume (SATV) correlated significantly with hepatic steatosis but none of the adipose tissue volumes had any correlation with other histological variables. Both SATV and TAT volume (TATV) correlated significantly with severity of liver disease as determined by NAS score whereas presence of MS or insulin resistance had no correlation with histological severity.
CONCLUSION: Both subcutaneous and total adipose tissue volume are related to the disease severity as determined by NAFLD activity score in Indian patients with NAFLD.
Authors:
Narendra S Choudhary; Ajay Duseja; Naveen Kalra; Ashim Das; Radha K Dhiman; Yogesh K Chawla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-22     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  478-86     Citation Subset:  IM    
Affiliation:
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Descriptor/Qualifier:
Adiposity / ethnology*
Adult
Asian Continental Ancestry Group*
Biopsy
Body Mass Index
Fatty Liver / diagnosis*,  ethnology*,  pathology,  physiopathology
Female
Humans
India / epidemiology
Insulin Resistance
Intra-Abdominal Fat / physiopathology*,  radiography
Liver / pathology*
Male
Metabolic Syndrome X / diagnosis,  ethnology,  pathology,  physiopathology
Middle Aged
Obesity / diagnosis*,  ethnology,  physiopathology,  radiography
Prospective Studies
Severity of Illness Index
Subcutaneous Fat / physiopathology*,  radiography
Tomography, X-Ray Computed
Waist Circumference

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