Document Detail

The adipocyte as an endocrine cell.
MedLine Citation:
PMID:  18775362     Owner:  NLM     Status:  MEDLINE    
Adipose tissue contains many cell types. Among the more abundant are adipocytes, preadipocytes, immune cells, and endothelial cells. During times of excess caloric intake, these cells have to adjust and remodel to accommodate the increased demand for triglyceride storage. Based on a comprehensive analysis of the total adipose tissue secretome, this article focuses on three areas of adipokine biology: (1) How does the adipocyte interact with the extracellular matrix over the course of obesity? (2) Does the adipocyte, per se, play a role in the innate immune response? (3) How is the angiogenic profile of adipose tissue linked to the development of insulin resistance? The authors present a comprehensive overview of all of the currently available secreted adipose tissue products that have been identified at the protein level.
Nils Halberg; Ingrid Wernstedt-Asterholm; Philipp E Scherer
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  37     ISSN:  0889-8529     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-11-04     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  753-68, x-xi     Citation Subset:  IM    
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MeSH Terms
Adipocytes / physiology*
Adipokines / physiology*
Matrix Metalloproteinases / physiology
Neovascularization, Physiologic
PPAR gamma / physiology
Grant Support
R01 CA112023/CA/NCI NIH HHS; R01 CA112023-04/CA/NCI NIH HHS; R01 DK055758/DK/NIDDK NIH HHS; R01 DK055758-09/DK/NIDDK NIH HHS; R24 DK071030/DK/NIDDK NIH HHS; R24 DK071030-04/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Adipokines; 0/PPAR gamma; EC 3.4.24.-/Matrix Metalloproteinases

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