Document Detail

The adipocyte as an active participant in energy balance and metabolism.
MedLine Citation:
PMID:  17498506     Owner:  NLM     Status:  MEDLINE    
Obesity is responsible for the mounting incidence of metabolic disease in adult and pediatric populations. Understanding of the pathogenesis and maintenance of the obese state has advanced rapidly over the past 10 years. Bodily energy reserves are managed actively by complex systems that regulate food intake, substrate partitioning, and energy expenditure. An underlying assumption that circulating factors released from storage organs were able to signal bodily energy reserves was confirmed with the discovery of the leptin system. This proof of concept has spurred on the discovery of a multitude of other adipocyte-generated factors. These circulating factors signal to the brain and other organs of metabolic importance, including adipose tissue, liver, muscle, and the immune system. Adipose-derived factors have numerous implications for the basic biology of obesity and provide prospective targets for the amelioration of obesity and its adverse metabolic consequences. In this review we detail the current understanding of leptin as a prototypical adipose tissue-derived hormone related to appetite and obesity. We also describe other important adipose-derived factors in relation to their metabolic effect.
Michael K Badman; Jeffrey S Flier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  132     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-03     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2103-15     Citation Subset:  AIM; IM    
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
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MeSH Terms
Adipocytes / metabolism*
Energy Metabolism / physiology*
Leptin / metabolism*
Obesity / physiopathology*
Signal Transduction
Grant Support
DKR37 28082//PHS HHS
Reg. No./Substance:

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