| The adipocyte as an active participant in energy balance and metabolism. | |
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MedLine Citation:
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PMID: 17498506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is responsible for the mounting incidence of metabolic disease in adult and pediatric populations. Understanding of the pathogenesis and maintenance of the obese state has advanced rapidly over the past 10 years. Bodily energy reserves are managed actively by complex systems that regulate food intake, substrate partitioning, and energy expenditure. An underlying assumption that circulating factors released from storage organs were able to signal bodily energy reserves was confirmed with the discovery of the leptin system. This proof of concept has spurred on the discovery of a multitude of other adipocyte-generated factors. These circulating factors signal to the brain and other organs of metabolic importance, including adipose tissue, liver, muscle, and the immune system. Adipose-derived factors have numerous implications for the basic biology of obesity and provide prospective targets for the amelioration of obesity and its adverse metabolic consequences. In this review we detail the current understanding of leptin as a prototypical adipose tissue-derived hormone related to appetite and obesity. We also describe other important adipose-derived factors in relation to their metabolic effect. |
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Authors:
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Michael K Badman; Jeffrey S Flier |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Gastroenterology Volume: 132 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-14 Completed Date: 2007-07-03 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
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Languages: eng Pagination: 2103-15 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism* Animals Eating* Energy Metabolism / physiology* Humans Leptin / metabolism* Obesity / physiopathology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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DKR37 28082//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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