Document Detail

The adhesiveness of human blood platelets and thyroid function.
MedLine Citation:
PMID:  1124657     Owner:  NLM     Status:  MEDLINE    
Hypothyroidism is associated with severe coronary atherosclerosis. In spite of this the reported incidence of angina pectoris and myocardial infarction in untreated hypothyroidism is small. Since many authors consider the formation of a thrombus in coronary arteries to be the final event of the process which leads to myocardial infarction, changes in the platelet function may explain the paradoxical rarity of myocardial infarction in untreated hypothyroidism. To evaluate this hypothesis, platelet adhesiveness has been estimated before and after treatment in 9 hypothyroid and 16 thyrotoxic patients. In thyrotoxicosis the platelet adhesiveness was significantly increased, but decreased to normal after treatment. In hypothyroidism platelet adhesiveness was abnormally low but increased to normal value after thyroid hormone replacement. This may be an important factor in precipitating myocardial infarction in patients with hypothyroidism and coronary artery atherosclerosis.
A J Hellem; E Segaard; J H Solem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  197     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:    1975 Jan-Feb
Date Detail:
Created Date:  1975-07-02     Completed Date:  1975-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  15-7     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Disease / blood
Hyperthyroidism / blood*,  therapy
Hypothyroidism / blood*,  drug therapy,  therapy
Myocardial Infarction / blood,  chemically induced
Platelet Adhesiveness*
Thyroid Hormones / adverse effects,  therapeutic use
Reg. No./Substance:
0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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