| The adhesiveness of human blood platelets and thyroid function. | |
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MedLine Citation:
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PMID: 1124657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypothyroidism is associated with severe coronary atherosclerosis. In spite of this the reported incidence of angina pectoris and myocardial infarction in untreated hypothyroidism is small. Since many authors consider the formation of a thrombus in coronary arteries to be the final event of the process which leads to myocardial infarction, changes in the platelet function may explain the paradoxical rarity of myocardial infarction in untreated hypothyroidism. To evaluate this hypothesis, platelet adhesiveness has been estimated before and after treatment in 9 hypothyroid and 16 thyrotoxic patients. In thyrotoxicosis the platelet adhesiveness was significantly increased, but decreased to normal after treatment. In hypothyroidism platelet adhesiveness was abnormally low but increased to normal value after thyroid hormone replacement. This may be an important factor in precipitating myocardial infarction in patients with hypothyroidism and coronary artery atherosclerosis. |
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Authors:
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A J Hellem; E Segaard; J H Solem |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 197 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1975 Jan-Feb |
Date Detail:
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Created Date: 1975-07-02 Completed Date: 1975-07-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 15-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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blood Humans Hyperthyroidism / blood*, therapy Hypothyroidism / blood*, drug therapy, therapy Myocardial Infarction / blood, chemically induced Platelet Adhesiveness* Thyroid Hormones / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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