Document Detail

The adhesiveness of human blood platelets and thyroid function.
MedLine Citation:
PMID:  1124657     Owner:  NLM     Status:  MEDLINE    
Hypothyroidism is associated with severe coronary atherosclerosis. In spite of this the reported incidence of angina pectoris and myocardial infarction in untreated hypothyroidism is small. Since many authors consider the formation of a thrombus in coronary arteries to be the final event of the process which leads to myocardial infarction, changes in the platelet function may explain the paradoxical rarity of myocardial infarction in untreated hypothyroidism. To evaluate this hypothesis, platelet adhesiveness has been estimated before and after treatment in 9 hypothyroid and 16 thyrotoxic patients. In thyrotoxicosis the platelet adhesiveness was significantly increased, but decreased to normal after treatment. In hypothyroidism platelet adhesiveness was abnormally low but increased to normal value after thyroid hormone replacement. This may be an important factor in precipitating myocardial infarction in patients with hypothyroidism and coronary artery atherosclerosis.
A J Hellem; E Segaard; J H Solem
Related Documents :
3694297 - The relative risk of myocardial infarction in patients who have high blood pressure and...
21258567 - Experimental models of duchenne muscular dystrophy: relationship with cardiovascular di...
805037 - Effectiveness of isosorbide dinitrate and nitroglycerin in relieving angina pectoris du...
21458817 - Regional analysis of dynamic deformation characteristics of native aortic valve leaflets.
2306837 - Do changes in pulmonary capillary wedge pressure adequately reflect myocardial ischemia...
15940587 - Stroke knowledge and misconceptions among survivors of stroke and a non-stroke survivor...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  197     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:    1975 Jan-Feb
Date Detail:
Created Date:  1975-07-02     Completed Date:  1975-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  15-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Disease / blood
Hyperthyroidism / blood*,  therapy
Hypothyroidism / blood*,  drug therapy,  therapy
Myocardial Infarction / blood,  chemically induced
Platelet Adhesiveness*
Thyroid Hormones / adverse effects,  therapeutic use
Reg. No./Substance:
0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Studies of urinary bladder dysfunction in amyloidosis with polyneuropathy.
Next Document:  Thalassaemia minor. Twelve patients in two Norwegian families.