Document Detail

An adenovirus infection of the kidney of Franklin's ground squirrels (Spermophilus franklini) in Saskatchewan, Canada.
MedLine Citation:
PMID:  2848139     Owner:  NLM     Status:  MEDLINE    
During routine pathological studies of Franklin's ground squirrels (Spermophilus franklini) collected during a predator control program, basophilic intranuclear inclusions were found in the collecting tubule epithelium of the renal papillae in seven of 13 squirrels. This was associated with marked karyomegaly in affected cells. An inflammatory response was not seen in the adjacent tissues. Electron microscopic examination of affected cells demonstrated that the enlarged nuclei contained numerous virus-like particles. Autoculture and serial passage of renal medullary cells resulted in the isolation of virus particles producing intranuclear inclusions and cytopathic effect. The virus possessed properties typical of adenoviruses, but showed no evidence of hemagglutinating activity with a range of species of erythrocytes tested under several temperature conditions. The isolates were relatively host-cell specific; they failed to grow in hamster and rabbit kidney cell lines and in ground squirrel kidney cortical cells.
P J Durham; F A Leighton; G A Wobeser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of wildlife diseases     Volume:  24     ISSN:  0090-3558     ISO Abbreviation:  J. Wildl. Dis.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244160     Medline TA:  J Wildl Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-41     Citation Subset:  IM    
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Adenoviridae Infections / pathology,  veterinary*
Centrifugation, Density Gradient
Hemagglutination Tests
Kidney Diseases / pathology,  veterinary*
Microscopy, Electron
Sciuridae / microbiology*
Serial Passage
Virus Cultivation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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