Document Detail

Müllerian adenosarcoma of vagina arising in persistent endometriosis: report of a case and review of the literature.
MedLine Citation:
PMID:  12893226     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary adenosarcoma arising in vaginal endometriosis poses a diagnostic challenge, especially in superficial vaginal biopsies. CASE: A 56-year-old woman, with a prior diagnosis of ovarian endometriosis, presented with a rapidly enlarging mass of the vaginal vault. Two prior biopsies were benign and showed endometriosis. The third vaginal biopsy revealed benign endometriotic glands cuffed by a cellular stroma with moderate cytologic atypia, a histological appearance diagnostic of Müllerian adenosarcoma. A 16-cm vaginal mass that had infiltrated the pelvic structures was resected. CONCLUSIONS: Close clinical follow-up of extrauterine endometriosis and clinical-pathologic correlation is necessary. Histological features such as cellular stromal cuffing around benign endometriotic glands are critical in arriving at a timely diagnosis of adenosarcoma in patients with persistent extrauterine endometriosis, even in superficial vaginal biopsies.
Lanting Liu; Susan Davidson; Meenakshi Singh
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Gynecologic oncology     Volume:  90     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-09-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
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MeSH Terms
Adenosarcoma / etiology*,  pathology
Endometriosis / complications*,  pathology
Middle Aged
Mixed Tumor, Mullerian / etiology*,  pathology
Vaginal Neoplasms / etiology*,  pathology

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