Document Detail

The additive protective effects of hypothermia and chemical cardioplegia during ischemic cardiac arrest in the dog.
MedLine Citation:
PMID:  7350386     Owner:  NLM     Status:  MEDLINE    
In clinical use cardioplegia is usually combined with local cardiac hypothermia, whose powerful protective effects make it difficult to assess the contributions made by the cardioplegic solution. The additive protective effects of hypothermia and of an experimental cardioplegic infusate were studied in 20 dogs which were subjected to 120 minutes of myocardial ischemia at 20 degrees C. In the hypothermic group 10 hearts were infused with a noncardioplegic solution at 20 degrees C at the onset and after 60 minutes of ischemia. In the cardioplegia plus hypothermia group of 10 hearts identical infusion conditions were followed, with the cardioplegia solution at 20 degrees C. Measurements of ventricular function before and after bypass revealed significantly better recoveries in the cardioplegic group than in the hypothermic group. Recoveries of cardiac output, left ventricular minute work, and dP/dt in the cardioplegia group were 92%, 62% and 91%, respectively, whereas in the hypothermia group the values were 38%, 17%, and 43%, respectively. Parallel biochemical assessments from biopsies revealed that postischemic myocardial adenosine triphosphate (ATP) content was unchanged from control in the cardioplegia group but fell significantly to 56% of control in the hypothermia group. Assessment of myocardial integrity by birefringence showed no change in the cardioplegia group but a deterioration in the hypothermia group. These results demonstrate that chemical cardioplegia when combined with hypothermia affords additional protection to the ischemic heart.
F L Rosenfeldt; D J Hearse; S Canković-Darracott; M V Braimbridge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  79     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-38     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Blood Pressure
Cardiac Output
Coronary Circulation*
Heart Arrest, Induced / methods*
Heart Rate
Hypothermia, Induced / methods*
Myocardial Contraction
Myocardium / metabolism,  ultrastructure
Phosphocreatine / metabolism
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

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