Document Detail

An additive interaction between different qualities of dyspnea produced in normal human subjects.
MedLine Citation:
PMID:  16860616     Owner:  NLM     Status:  MEDLINE    
We evaluated the sensation of dyspnea induced by hypercapnia alone and a combination of hypercapnia and flow-resistive loading by the use of visual analogue scale (VAS) and the use of 13 listed descriptors in 23 healthy subjects. Hypercapnia alone caused a modest degree of dyspnea characterized by both air hunger and work/effort sensations. An addition of inspiratory flow-resistive loading (IRL) caused an increase in inspiratory difficulty and some attenuation of 'work/effort.' The addition of expiratory flow-resistive loading (ERL) caused an increase in expiratory difficulty and attenuation of 'air hunger.' The addition of both IRL and ERL caused a marked increase in dyspnea, the amount of which was close to the sum of the increases obtained individually by IRL and by ERL, while the quality of dyspnea was characterized predominantly by work/effort. These results suggest that despite the difference in quality of sensations, the intensity of dyspnea would sum linearly when the two kinds of loads are presented at the same time.
Takashi Nishino; Shiroh Isono; Teruhiko Ishikawa; Norihiro Shinozuka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-24
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  155     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  14-21     Citation Subset:  IM    
Department of Anesthesiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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MeSH Terms
Air Pressure
Airway Resistance / physiology
Carbon Dioxide / diagnostic use,  metabolism
Data Interpretation, Statistical
Dyspnea / physiopathology*,  psychology
Energy Metabolism / physiology
Hypercapnia / physiopathology
Respiratory Mechanics / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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