| The addition of soybean phosphatidylcholine to triglyceride increases suppressive effects on food intake and gastric emptying in rats. | |
| | |
MedLine Citation:
|
PMID: 12730406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The physiologic roles of dietary lecithin have not yet been clearly defined. We examined the effects of soybean lecithin on gastric emptying (Experiments 1 and 2) and food intake (Experiment 3) in rats. Male Wistar rats were fed 2 g of a 20 g lipid/100 g diet containing various levels of lecithin after 24 h of food deprivation; gastric contents were collected 3 h after feeding (Experiment 1). In Experiment 2, the effects of lecithin and a CCK-A receptor antagonist on gastric emptying were examined using a modified phenol red recovery technique. In Experiment 3, their effects on food intake were examined after an intraduodenal infusion of an oil emulsion containing 50 mg soybean oil (SO) or SO partially replaced by lecithin (14-50%). Gastric emptying rates of the lipid and protein in the test diet (Experiment 1) or of phenol red (Experiment 2) were lower in the groups administered lecithin. Food intake for 60 min was lower in rats infused with the oil emulsion containing lecithin (25, 50%) than in rats not administered lecithin. The suppressive effects of lecithin on gastric emptying and food intake were largely reduced by devazepide. These results demonstrate that oil containing lecithin inhibits gastric emptying and food intake, and the effects are associated in part with CCK release. |
| | |
Authors:
|
Megumi Nishimukai; Hiroshi Hara; Yoritaka Aoyama |
Related Documents
:
|
20868426 - Oxytocin reduces satiety scores without affecting the volume of nutrient intake or gast... 23397356 - Selenium bioaccessibility and bioavailability in se-enriched food supplements. 6806786 - Comparison of trh and anorexigenic peptide on food intake and gastrointestinal secretions. 964556 - Leiomyosarcomas of the small intestine induced in dogs by n-methul-n'-nitro-n-nitrosogu... 9366866 - Food acquisition habits, nutrient intakes, and anthropometric data of havasupai adults. 19754146 - Quantitation of s-methylmethionine in raw vegetables and green malt by a stable isotope... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Journal of nutrition Volume: 133 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-05-05 Completed Date: 2003-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 1255-8 Citation Subset: IM |
Affiliation:
|
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animal Feed Animals Devazepide / administration & dosage, pharmacology Emulsions / administration & dosage, pharmacology Energy Intake / drug effects* Gastric Emptying / drug effects* Infusions, Parenteral Male Phosphatidylcholines / pharmacology* Plant Oils / administration & dosage, pharmacology Rats Rats, Wistar Receptor, Cholecystokinin A Receptors, Cholecystokinin / antagonists & inhibitors Soybeans* Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Emulsions; 0/Phosphatidylcholines; 0/Plant Oils; 0/Receptor, Cholecystokinin A; 0/Receptors, Cholecystokinin; 0/Triglycerides; 103420-77-5/Devazepide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Soy protein isolate enhances hepatic copper accumulation and cell damage in LEC rats.
Next Document: Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells.