| The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle. | |
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MedLine Citation:
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PMID: 18775090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was conducted evaluating the effect of long-term Cu deficiency, with or without high Mn, on growth, gene expression and Cu status of beef cattle. Twenty-one Angus calves were born to cows receiving one of the following treatments: (1) 10 mg supplemental Cu/kg DM (+Cu); (2) no supplemental Cu and 2 mg Mo/kg DM ( - Cu); (3) - Cu diet plus 500 mg supplemental Mn/kg DM ( - Cu+Mn). Calves were weaned at approximately 183 d of age and individually fed throughout the growing and finishing phases. Plasma Cu was lower (P < 0.01) in - Cu calves compared with +Cu calves while high dietary Mn further depressed (P < 0.01) plasma Cu in - Cu+Mn calves v. - Cu calves. Liver Cu concentrations in +Cu calves were greater (P < 0.01) than in - Cu calves, with no differences between - Cu and - Cu+Mn calves. The daily body-weight gain of +Cu calves was greater (P < 0.01) than - Cu calves during the period from birth to weaning, but did not differ during the growing phase. - Cu+Mn calves gained less (P < 0.05) than - Cu calves during the growing phase. DM intake was lower (P < 0.01) in - Cu+Mn calves v. - Cu calves, and did not differ among +Cu and - Cu calves. The relative gene expression of cytochrome c oxidase in the liver was lower (P < 0.05) in - Cu calves compared with +Cu or - Cu+Mn calves. In conclusion, feeding a Cu - deficient diet in combination with high Mn negatively affected the growth and Cu status of beef cattle. |
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Authors:
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Stephanie L Hansen; Melissa S Ashwell; Leon R Legleiter; Robert S Fry; Karen E Lloyd; Jerry W Spears |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-08 |
Journal Detail:
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Title: The British journal of nutrition Volume: 101 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-03 Completed Date: 2009-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1068-78 Citation Subset: IM |
Affiliation:
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Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed* Animal Nutritional Physiological Phenomena* Animals Body Weight / drug effects Cattle / growth & development, metabolism* Copper / deficiency* Cyclooxygenase 1 / genetics Depression, Chemical Female Gene Expression / drug effects Liver / metabolism Male Manganese / administration & dosage*, analysis Nutritional Status Random Allocation Reverse Transcriptase Polymerase Chain Reaction / methods Superoxide Dismutase / genetics Time Factors |
| Chemical | |
Reg. No./Substance:
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7439-96-5/Manganese; 7440-50-8/Copper; EC 1.14.99.1/Cyclooxygenase 1; EC 1.15.1.-/superoxide dismutase 1; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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