Document Detail

The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise.
MedLine Citation:
PMID:  15719265     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the effects of ingesting an oral supplement containing 4-Hydroxyisoleucine (4-OH-Ile, isolated from fenugreek seeds [Trigonella foenum-graecum]) with a glucose beverage on rates of post-exercise muscle glycogen resynthesis in trained male cyclists. Following an overnight fast (12 hr), subjects completed a 90-minute glycogen depletion ride after which a muscle biopsy was obtained from the vastus lateralis. Immediately and 2 hours after the muscle biopsy, subjects ingested either an oral dose of dextrose (Glu) (1.8 BW(-1)) or 4-OH-Ile supplement (Glu+4-OH-Ile, including 2.0 4-OH-Ile with the same oral dose of dextrose) with a second muscle biopsy 4 hours after exercise. Post exercise muscle glycogen concentration was similar for both trials. Overall, there was a significant increase in glucose and insulin concentrations from time 0 throughout the majority of the 4-hour recovery period, with no significant differences between the two trials at any time point. Although muscle glycogen concentration significantly increased from immediately post exercise to 4 hr of recovery for both trials, the net rate of muscle glycogen resynthesis was 63% greater during Glu+4-OH-Ile (10.6+/-3.3 vs. 6.5+/-2.6 wet wt.(-1).hr.(-1) for the Glu+4-OH-Ile and Glu trials, respectively). These data demonstrate that when the fenugreek extract supplement (4-OH-Ile) is added to a high oral dose of dextrose, rates of post-exercise glycogen resynthesis are enhanced above dextrose alone.
B C Ruby; S E Gaskill; D Slivka; S G Harger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-02
Journal Detail:
Title:  Amino acids     Volume:  28     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-18     Completed Date:  2005-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Department of Health and Human Performance, The University of Montana, Missoula, Montana 59812-1825, USA.
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MeSH Terms
Blood Glucose / analysis
Dietary Supplements
Glucose / pharmacology*
Glycogen / metabolism*
Insulin / blood
Isoleucine / analogs & derivatives,  pharmacology
Muscle, Skeletal / drug effects,  metabolism*
Plant Extracts / pharmacology*
Trigonella / chemistry*
Reg. No./Substance:
0/4-hydroxyisoleucine; 0/Blood Glucose; 0/Plant Extracts; 11061-68-0/Insulin; 50-99-7/Glucose; 73-32-5/Isoleucine; 9005-79-2/Glycogen

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