Document Detail

The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction.
MedLine Citation:
PMID:  15354916     Owner:  NLM     Status:  MEDLINE    
Clonidine has been shown to prolong sensory analgesia when given as an adjunct to peripheral nerve blocks but has not been evaluated when given in conjunction with a femoral-sciatic nerve block. The purpose of this investigation was to determine whether the addition of clonidine to a femoral-sciatic nerve block would prolong the duration of sensory analgesia in groups of patients undergoing anterior cruciate ligament (ACL) reconstruction. This prospective, randomized, double-blind investigation was performed on 64 subjects undergoing ACL reconstruction. Patients were assigned randomly to receive a femoral-sciatic nerve block using 30 mL of 0.5% bupivacaine with 1:200,000 epinephrine (control group) or 30 mL of 0.5% bupivacaine with 1:200,000 epinephrine and 1 microg/kg of clonidine (experimental group). Variables measured included demographics, timed pain intensity measurements, postoperative analgesic consumption, duration of analgesia, and patient satisfaction. No significant differences were noted between groups for pain intensity scores, duration of sensory analgesia, postoperative analgesic requirements, or overall patient satisfaction. Both groups reported minimal amounts of postoperative pain and high analgesic satisfaction scores. Based on our results, we do not recommend the addition of clonidine to a femoral-sciatic nerve block when given to facilitate postoperative analgesia in patients undergoing ACL reconstruction.
Darren J Couture; Heather M Cuniff; John P Maye; Joseph Pellegrini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  AANA journal     Volume:  72     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-09     Completed Date:  2004-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  N    
Naval Hospital Bremerton, Wash, USA.
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MeSH Terms
Analgesics / pharmacology,  therapeutic use*
Anesthetics, Local / pharmacology,  therapeutic use*
Anterior Cruciate Ligament / injuries,  surgery*
Bupivacaine / pharmacology,  therapeutic use*
Clonidine / pharmacology,  therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Femoral Nerve* / drug effects
Naval Medicine
Nerve Block / methods*,  psychology
Pain, Postoperative / diagnosis,  etiology,  prevention & control
Patient Satisfaction
Prospective Studies
Reconstructive Surgical Procedures / adverse effects
Sciatic Nerve* / drug effects
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Analgesics; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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