Document Detail

The addition of choline to parenteral nutrition.
MedLine Citation:
PMID:  19874943     Owner:  NLM     Status:  MEDLINE    
Choline is a quaternary amine endogenously synthesized from the amino acid methionine or absorbed via the portal circulation. It is ubiquitous in the diet, although it has a greater presence in organ meats. Choline is an essential component of all cell membranes, and has been considered a required dietary nutrient since 1998 by the US Institute of Medicine's Food and Nutrition Board. Choline is necessary for DNA repair, mediated by its role as a methyl donor. It also serves as the precursor for the neurotransmitter acetylcholine. Evidence has accumulated that hepatic steatosis, which occurs during parenteral nutrition therapy, develops as a result of choline deficiency because endogenous production of choline from parenterally infused methionine is deficient. In addition, memory deficits and skeletal muscle abnormalities have been described, and choline deficiency appears to activate cellular apoptosis. Provision of intravenous choline ameliorates hepatic steatosis associated with parenteral nutrition infusion.
Alan L Buchman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  137     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S119-28     Citation Subset:  AIM; IM    
Intestinal Rehabilitation and Transplant Center, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
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MeSH Terms
Burns / complications
Choline / administration & dosage*,  metabolism,  toxicity
Choline Deficiency / complications,  diagnosis,  physiopathology
Kidney Failure / complications
Liver Cirrhosis / complications
Liver Diseases / etiology
Parenteral Nutrition* / adverse effects
Practice Guidelines as Topic
Sepsis / complications
Sexual Behavior
Wounds and Injuries / complications
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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