| The addition of choline to parenteral nutrition. | |
| | |
MedLine Citation:
|
PMID: 19874943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Choline is a quaternary amine endogenously synthesized from the amino acid methionine or absorbed via the portal circulation. It is ubiquitous in the diet, although it has a greater presence in organ meats. Choline is an essential component of all cell membranes, and has been considered a required dietary nutrient since 1998 by the US Institute of Medicine's Food and Nutrition Board. Choline is necessary for DNA repair, mediated by its role as a methyl donor. It also serves as the precursor for the neurotransmitter acetylcholine. Evidence has accumulated that hepatic steatosis, which occurs during parenteral nutrition therapy, develops as a result of choline deficiency because endogenous production of choline from parenterally infused methionine is deficient. In addition, memory deficits and skeletal muscle abnormalities have been described, and choline deficiency appears to activate cellular apoptosis. Provision of intravenous choline ameliorates hepatic steatosis associated with parenteral nutrition infusion. |
| | |
Authors:
|
Alan L Buchman |
Related Documents
:
|
457813 - Plasmalemma invaginations of physarum dependent on the nutritional content of the plasm... 19042573 - Role of food perceptions in food selection of the elderly. 7547053 - Absorption of nitrogen dioxide and nitric oxide by soda lime. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Gastroenterology Volume: 137 ISSN: 1528-0012 ISO Abbreviation: Gastroenterology Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-30 Completed Date: 2010-01-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
|
Languages: eng Pagination: S119-28 Citation Subset: AIM; IM |
Affiliation:
|
Intestinal Rehabilitation and Transplant Center, Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. a-buchman@northwestern.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Burns / complications Child Choline / administration & dosage*, metabolism, toxicity Choline Deficiency / complications, diagnosis, physiopathology Female Humans Kidney Failure / complications Lactation Liver Cirrhosis / complications Liver Diseases / etiology Parenteral Nutrition* / adverse effects Practice Guidelines as Topic Pregnancy Sepsis / complications Sexual Behavior Wounds and Injuries / complications |
| Chemical | |
Reg. No./Substance:
|
62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin K in parenteral nutrition.
Next Document: Carnitine in parenteral nutrition.