Document Detail

The added value of embryo cryopreservation to cumulative ongoing pregnancy rates per IVF treatment: is cryopreservation worth the effort?
MedLine Citation:
PMID:  12503888     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To calculate the added benefit of a cryopreservation program to the cumulative ongoing pregnancy rate over a maximum of three cycles of IVF.
METHODS: A total of 1251 couples beginning their first IVF treatment between January 1995 and December 1999 were evaluated. Ongoing pregnancies from fresh and subsequent cryopreserved embryo transfer cycles were analyzed. Pregnancies arising from the cryopreservation cycle were considered to augment the cumulative pregnancy rate when no ongoing pregnancy arose from the fresh embryo transfer cycle.
RESULTS: The ongoing pregnancy rate per cryopreserved embryo transfer was 11.7%. The cumulative ongoing pregnancy rate following three successive started fresh IVF cycles was 42.5%. When pregnancies arising from the transfer of thawed cryopreserved embryos were included, the cumulative ongoing pregnancy rate increased to 43.8%, rising to 44.8% when extrapolated data from as yet unthawed embryos was included.
CONCLUSIONS: When analyzed in these terms, the supplementary benefit of cryopreserving supranumerical embryos appears limited.
D de Jong; M J C Eijkemans; N G M Beckers; R V Pruijsten; B C J M Fauser; N S Macklon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  19     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-06-06     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-8     Citation Subset:  IM    
Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands.
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MeSH Terms
Cryopreservation / statistics & numerical data*
Embryo Transfer / statistics & numerical data
Embryo, Mammalian*
Fertilization in Vitro / methods,  statistics & numerical data*
Longitudinal Studies
Pregnancy Rate*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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