| The adaptive immune system in diseases of the central nervous system. | |
| | |
MedLine Citation:
|
PMID: 22466659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tissues of the CNS, such as the brain, optic nerves, and spinal cord, may be affected by a range of insults including genetic, autoimmune, infectious, or neurodegenerative diseases and cancer. The immune system is involved in the pathogenesis of many of these, either by causing tissue damage or alternatively by responding to disease and contributing to repair. It is clearly vital that cells of the immune system patrol the CNS and protect against infection. However, in contrast to other tissues, damage caused by immune pathology in the CNS can be irreparable. The nervous and immune systems have, therefore, coevolved to permit effective immune surveillance while limiting immune pathology. Here we will consider aspects of adaptive immunity in the CNS and the retina, both in the context of protection from infection as well as cancer and autoimmunity, while focusing on immune responses that compromise health and lead to significant morbidity. |
| | |
Authors:
|
David C Wraith; Lindsay B Nicholson |
Related Documents
:
|
22507049 - Abnormal epidermal barrier in the pathogenesis of contact dermatitis. 22492309 - Sulfuretin from heartwood of rhus verniciflua triggers apoptosis through activation of ... 22633459 - Regulation of actin dynamics by protein kinase r control of gelsolin enforces basal inn... 22328149 - Alternative pathway of cell death in drosophila mediated by nf-κb transcription factor... 1397839 - Electromagnetic field effects on cells of the immune system: the role of calcium signal... 22504579 - Lupus and epstein-barr. 15226179 - Characterization of monocyte tissue factor activity induced by igg antiphospholipid ant... 14741709 - 15d-pgj2 inhibits oxidized ldl-induced macrophage proliferation by inhibition of gm-csf... 15295649 - Inhibiting apoptosis of ctll-2 cells to enhance their gvl effects via anti-fas ribozyme. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-04-02 |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-04-02 Completed Date: 2012-07-06 Revised Date: 2013-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
|
Languages: eng Pagination: 1172-9 Citation Subset: AIM; IM |
Affiliation:
|
School of Clinical Sciences, University of Bristol, Bristol, United Kingdom. D.C.Wraith@bristol.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptive Immunity
/
immunology* Animals Antigen Presentation Autoimmune Diseases of the Nervous System / immunology* Blood-Brain Barrier Central Nervous System / immunology* Central Nervous System Infections / immunology* Central Nervous System Neoplasms / immunology Humans Immunologic Surveillance Inflammation / immunology Mice Microglia / immunology Models, Immunological Models, Neurological Paraneoplastic Syndromes, Nervous System / immunology* Retina / immunology T-Lymphocyte Subsets / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Innate immunity in the central nervous system.
Next Document: Multiple sclerosis.