Document Detail

The acute toxicity of some organolead and organotin compounds in the rat, with particular reference to a gastric lesion.
MedLine Citation:
PMID:  7185885     Owner:  NLM     Status:  MEDLINE    
The acute toxicity of triphenyl, tributyl and dibutyllead in the rat appears to result from their irritating properties to membranes regardless of their route of administration. A more detailed examination of their oral toxicity has shown that a single dose inhibits gastric emptying with resulting fluid distension. A similar effect was observed with a number of other organolead and organotin compounds. Analysis of gastric fluid from pyloric ligated rats following an oral organolead dose showed increased concentrations of Na+ and glucose and decreased concentrations of H+ and K+. Dilation of the gastric mucosal microcirculation was also observed along with desquamation of surface mucous cells which resulted in shallow erosions of the upper portions of the gastric glands. It is suggested that oral dosing with a number of organoleads and, possibly, organotins has an effect on mucosal membranes that results in erosion of the gastric mucosa and increases permeability of the mucosal microcirculation. This would allow leakage of plasma constituents into interstitial fluid and ultimately the gastric lumen with back-diffusion of H+ into the gastric mucosa. Such a lesion would impair gastric function and reduce normal food and water consumption. The starvation and dehydration may then be the important factors for death that follows oral dosing with organolead and organotin compounds.
R D Verschoyle; R A Little
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  1     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
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MeSH Terms
Gastric Mucosa / drug effects*,  pathology
Lead / toxicity*
Lethal Dose 50
Organometallic Compounds / toxicity*
Organotin Compounds / toxicity*
Rats, Inbred Strains
Reg. No./Substance:
0/Organometallic Compounds; 0/Organotin Compounds; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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