| The acute toxicity of some organolead and organotin compounds in the rat, with particular reference to a gastric lesion. | |
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MedLine Citation:
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PMID: 7185885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute toxicity of triphenyl, tributyl and dibutyllead in the rat appears to result from their irritating properties to membranes regardless of their route of administration. A more detailed examination of their oral toxicity has shown that a single dose inhibits gastric emptying with resulting fluid distension. A similar effect was observed with a number of other organolead and organotin compounds. Analysis of gastric fluid from pyloric ligated rats following an oral organolead dose showed increased concentrations of Na+ and glucose and decreased concentrations of H+ and K+. Dilation of the gastric mucosal microcirculation was also observed along with desquamation of surface mucous cells which resulted in shallow erosions of the upper portions of the gastric glands. It is suggested that oral dosing with a number of organoleads and, possibly, organotins has an effect on mucosal membranes that results in erosion of the gastric mucosa and increases permeability of the mucosal microcirculation. This would allow leakage of plasma constituents into interstitial fluid and ultimately the gastric lumen with back-diffusion of H+ into the gastric mucosa. Such a lesion would impair gastric function and reduce normal food and water consumption. The starvation and dehydration may then be the important factors for death that follows oral dosing with organolead and organotin compounds. |
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Authors:
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R D Verschoyle; R A Little |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 1 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 247-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Gastric Mucosa / drug effects*, pathology Lead / toxicity* Lethal Dose 50 Male Organometallic Compounds / toxicity* Organotin Compounds / toxicity* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Organometallic Compounds; 0/Organotin Compounds; 7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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