Document Detail


The acute respiratory distress syndrome.
MedLine Citation:
PMID:  22850883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure that is often associated with multiple organ failure. Several clinical disorders can precipitate ARDS, including pneumonia, sepsis, aspiration of gastric contents, and major trauma. Physiologically, ARDS is characterized by increased permeability pulmonary edema, severe arterial hypoxemia, and impaired carbon dioxide excretion. Based on both experimental and clinical studies, progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors. Improved survival has been achieved with the use of lung-protective ventilation. Future progress will depend on developing novel therapeutics that can facilitate and enhance lung repair.
Authors:
Michael A Matthay; Lorraine B Ware; Guy A Zimmerman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-08-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-10-25     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2731-40     Citation Subset:  AIM; IM    
Affiliation:
Cardiovascular Research Institute and Departments of Medicine and Anesthesia, UCSF, San Francisco, CA, USA. michael.matthay@ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Lung Injury / etiology,  physiopathology,  therapy
Clinical Trials as Topic
Humans
Permeability
Pneumonia, Ventilator-Associated / etiology,  physiopathology,  therapy
Respiratory Distress Syndrome, Adult / etiology*,  physiopathology*,  therapy
Signal Transduction
Grant Support
ID/Acronym/Agency:
1RC1HL100121/HL/NHLBI NIH HHS; 5R01HL091754-03/HL/NHLBI NIH HHS; 5R37HL44525-23/HL/NHLBI NIH HHS; HL088263/HL/NHLBI NIH HHS; HL103836/HL/NHLBI NIH HHS; K24 HL103836/HL/NHLBI NIH HHS; P01A1053194//PHS HHS; R01A1087674//PHS HHS; R01HL101779/HL/NHLBI NIH HHS; R01HL51854/HL/NHLBI NIH HHS; R37 HL044525/HL/NHLBI NIH HHS; R37 HL051856/HL/NHLBI NIH HHS; R37HL51856/HL/NHLBI NIH HHS; U01HL10871301/HL/NHLBI NIH HHS
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