Document Detail


The acute inflammatory process, arachidonic acid metabolism and the mode of action of anti-inflammatory drugs.
MedLine Citation:
PMID:  6428879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arachidonic acid is a polyunsaturated fatty acid covalently bound in esterified form in the cell membranes of most body cells. Following irritation or injury, arachidonic acid is released and oxygenated by enzyme systems leading to the formation of an important group of inflammatory mediators, the eicosanoids. It is now recognised that eicosanoid release is fundamental to the inflammatory process. For example, the prostaglandins and other prostanoids, products of the cyclooxygenase enzyme pathway, have potent inflammatory properties and prostaglandin E2 is readily detectable in equine acute inflammatory exudates. The administration of nonsteroidal anti-inflammatory drugs results in inhibition of prostaglandin synthesis and this explains the mode of action of agents such as phenylbutazone and flunixin. Lipoxygenase enzymes metabolise arachidonic acid to a group of noncyclised eicosanoids, the leukotrienes, some of which are also important inflammatory mediators. They are probably of particular importance in leucocyte-mediated aspects of chronic inflammation. Currently available non-steroidal anti-inflammatory drugs, however, do not inhibit lipoxygenase activity. In the light of recent evidence, the inflammatory process is re-examined and the important emerging roles of both cyclo-oxygenase and lipoxygenase derived eicosanoids are explored. The mode of action of current and future anti-inflammatory drugs offered to the equine clinician can be explained by their interference with arachidonic acid metabolism.
Authors:
A J Higgins; P Lees
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Equine veterinary journal     Volume:  16     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  163-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / pharmacology
Animals
Anti-Inflammatory Agents / pharmacology*,  therapeutic use
Arachidonic Acid
Arachidonic Acids / metabolism*
Blood Coagulation
Chemotaxis
Complement System Proteins / physiology
Cyclooxygenase Inhibitors
Histamine / physiology
Horse Diseases / drug therapy,  metabolism,  physiopathology*
Horses
Inflammation / drug therapy,  metabolism,  veterinary*
Kinins / physiology
Lipoxygenase / metabolism
Lipoxygenase Inhibitors
Phenylbutazone / pharmacology
Prostaglandin-Endoperoxide Synthases / metabolism
Prostaglandins / biosynthesis
Serotonin / physiology
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents; 0/Arachidonic Acids; 0/Cyclooxygenase Inhibitors; 0/Kinins; 0/Lipoxygenase Inhibitors; 0/Prostaglandins; 50-33-9/Phenylbutazone; 50-67-9/Serotonin; 506-32-1/Arachidonic Acid; 51-45-6/Histamine; 9007-36-7/Complement System Proteins; EC 1.13.11.12/Lipoxygenase; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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