Document Detail

The acute effects of various cytotoxic compounds injected into the prostate glands of dogs.
MedLine Citation:
PMID:  417447     Owner:  NLM     Status:  MEDLINE    
The acute effects of direct injections with various cytotoxic compounds into the prostates of adult dogs were studied microscopically. The effects remained localised to the site of injection, with no diffusion of the agents into other areas of the prostate. No systemic effects were observed despite the high concentrations used. The main histological changes consisted of local aseptic necrosis at the injection site surrounded by atrophy of the acinar epithelium.
M Firstater; A Meshorer; A Tadmor; L Itzicovitch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urological research     Volume:  6     ISSN:  0300-5623     ISO Abbreviation:  Urol. Res.     Publication Date:  1978  
Date Detail:
Created Date:  1978-06-17     Completed Date:  1978-06-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / administration & dosage,  adverse effects*
Dactinomycin / adverse effects
Ethoglucid / adverse effects
Fluorouracil / adverse effects
Inflammation / etiology
Injections / methods
Mitomycins / adverse effects
Necrosis / etiology
Prostate / drug effects*
Thiotepa / adverse effects
Reg. No./Substance:
0/Antineoplastic Agents; 0/Mitomycins; 1954-28-5/Ethoglucid; 50-76-0/Dactinomycin; 51-21-8/Fluorouracil; 52-24-4/Thiotepa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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