Document Detail

The acute effects of intravenous nisoldipine on left ventricular function within 24 h after acute myocardial infarction.
MedLine Citation:
PMID:  1289100     Owner:  NLM     Status:  MEDLINE    
Nisoldipine is a calcium antagonist with potent coronary vasodilating effects in patients with chronic stable angina pectoris. We studied the acute effects of nisoldipine in six patients within 24 h (mean 14 +/- 4 h) after the onset of myocardial infarction. Nisoldipine was administered as a 4.5 micrograms kg-1 intravenous bolus over 3 min followed by intravenous infusion of 0.2 microgram kg-1 min-1 during 60 min. Radionuclide angiography, cardiac output and intra-arterial blood pressure measurements were performed before and during nisoldipine. Left ventricular ejection fraction increased from 48.3 +/- 10.3% to 55.3 +/- 11.8% (P = 0.034) during nisoldipine infusion. Regional wall motion score changed during nisoldipine infusion from 3.3 +/- 2.5 to 1.8 +/- 2.6 (P = 0.027). Cardiac output increased from 5.5 +/- 1.0 to 7.3 +/- 1.3 l min-1 (P = 0.0001). Heart rate increased from 78 +/- 12 to 88 +/- 11 beats.min-1 (P = 0.004). Mean arterial blood pressure decreased from 91.7 +/- 20.2 to 78.7 +/- 13.1 mmHg (P = 0.038). The rate-pressure product did not change significantly during nisoldipine infusion. It is concluded that nisoldipine improves global and regional left ventricular function in patients with acute myocardial infarction within the first 24 h. Our findings suggest that this effect is achieved without increasing myocardial oxygen demand.
J C Chin; E E van der Wall; V Manger Cats; A van der Laarse; J A Blokland; E J Pauwels; A V Bruschke
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-25     Completed Date:  1993-03-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1684-91     Citation Subset:  IM    
Department of Cardiology, University Hospital Leiden, The Netherlands.
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MeSH Terms
Cardiac Output / drug effects
Drug Administration Schedule
Gated Blood-Pool Imaging
Heart Ventricles / radionuclide imaging
Hemodynamics / drug effects
Infusions, Intravenous
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Nisoldipine / administration & dosage,  pharmacology*,  therapeutic use
Ventricular Function, Left / drug effects*
Reg. No./Substance:

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