Document Detail

The acute effect of a single very high dose of N-3 fatty acids on coagulation and fibrinolysis.
MedLine Citation:
PMID:  1448789     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to investigate the acute effect of a single very high dose of n-3 PUFA on coagulation and fibrinolysis. Forty healthy volunteers were randomized into two groups to receive either 20 grams of n-3 PUFA or 20 grams of n-6 PUFA as a single dose at 6 p.m. with their evening meal. Coagulation and fibrinolysis were evaluated in the fasting state at 8 a.m. the next morning and compared to values obtained at 8 a.m. the day before, when the participants were on their habitual diets. PAI-1 activity in plasma increased by a mean of 62% in subjects randomized to receive n-3 PUFA despite that no changes could be demonstrated in t-PA antigen levels. PAI-1 activity was unaltered in the 20 controls receiving n-6 PUFA. Plasma fibrinogen, coagulation factor VII, thrombin-antithrombin complexes and D-dimer did not significantly change after either supplement. The substantial increase in levels of PAI-1 activity in plasma after a single very high dose of n-3 PUFA may limit the usefulness of single very high doses of n-3 PUFA in acute clinical conditions.
J M Møller; N Svaneborg; H H Lervang; K Varming; P Madsen; J Dyerberg; E B Schmidt
Related Documents :
15212489 - Bound ferulic acid from bran is more bioavailable than the free compound in rat.
1453579 - Effects of dietary protein restriction and oil type on the early progression of murine ...
20823489 - Obesity, the metabolic syndrome, and type 2 diabetes in developing countries: role of d...
15884759 - N-3 fatty acid enrichment of edible tissue of poultry: a review.
19046819 - Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role ...
11221959 - Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins e...
8923179 - Growth, reproductive performance, mammary development, and milk production of beef heif...
23446559 - Fat necrosis in autologous abdomen-based breast reconstruction: a systematic review.
20071779 - Deleted in breast cancer-1 regulates sirt1 activity and contributes to high-fat diet-in...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis research     Volume:  67     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-30     Completed Date:  1992-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  569-77     Citation Subset:  IM    
Department of Endocrinology, Aalborg Hospital, Copenhagen.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Coagulation / drug effects*
Fatty Acids, Omega-3 / pharmacology*
Fibrinolysis / drug effects*
Middle Aged
Plasminogen Activator Inhibitor 1 / analysis*
Tissue Plasminogen Activator / analysis
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Plasminogen Activator Inhibitor 1; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  1-Deamino-8 D-arginine vasopressin decreases the production of 13-hydroxyoctadecadienoic acid by end...
Next Document:  The vascular plasminogen activator as source of the fibrinolytic potential observed during cardiopul...