Document Detail


The acute effect of a single very high dose of N-3 fatty acids on coagulation and fibrinolysis.
MedLine Citation:
PMID:  1448789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the study was to investigate the acute effect of a single very high dose of n-3 PUFA on coagulation and fibrinolysis. Forty healthy volunteers were randomized into two groups to receive either 20 grams of n-3 PUFA or 20 grams of n-6 PUFA as a single dose at 6 p.m. with their evening meal. Coagulation and fibrinolysis were evaluated in the fasting state at 8 a.m. the next morning and compared to values obtained at 8 a.m. the day before, when the participants were on their habitual diets. PAI-1 activity in plasma increased by a mean of 62% in subjects randomized to receive n-3 PUFA despite that no changes could be demonstrated in t-PA antigen levels. PAI-1 activity was unaltered in the 20 controls receiving n-6 PUFA. Plasma fibrinogen, coagulation factor VII, thrombin-antithrombin complexes and D-dimer did not significantly change after either supplement. The substantial increase in levels of PAI-1 activity in plasma after a single very high dose of n-3 PUFA may limit the usefulness of single very high doses of n-3 PUFA in acute clinical conditions.
Authors:
J M Møller; N Svaneborg; H H Lervang; K Varming; P Madsen; J Dyerberg; E B Schmidt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis research     Volume:  67     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-30     Completed Date:  1992-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  569-77     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Aalborg Hospital, Copenhagen.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation / drug effects*
Fatty Acids, Omega-3 / pharmacology*
Female
Fibrinolysis / drug effects*
Humans
Male
Middle Aged
Plasminogen Activator Inhibitor 1 / analysis*
Tissue Plasminogen Activator / analysis
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Plasminogen Activator Inhibitor 1; EC 3.4.21.68/Tissue Plasminogen Activator

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