| The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. | |
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MedLine Citation:
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PMID: 21813917 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study tested the acute anti-inflammatory and immune-modulating influence of a quercetin-based supplement consumed by endurance athletes 15 min before an intense 2-hr run. In this randomized, crossover study, 20 runners (11 men, 9 women, age 38.4 ± 2.1 yr) completed two 2-hr treadmill runs at 70% VO2max (3 wk apart). Subjects ingested either 4 quercetin-based chews (Q-chew) or placebo chews (PL) 15 min before the runs. The 4 Q-chews provided 1,000 mg quercetin, 120 mg epigallocatechin 3-gallate, 400 mg isoquercetin, 400 mg each eicosapentaenoic acid and docosahexaenoic acid, 1,000 mg vitamin C, and 40 mg niacinamide. Subjects provided blood samples 30 min before, immediately after, and 1 hr postexercise and were analyzed for plasma quercetin, total blood leukocytes (WBC), C-reactive protein (CRP), 9 cytokines (IL-6, TNFα, GM-CSF, IFNγ, IL-1β, IL-2, IL-8, IL-10, and IL-12p70), granulocyte (GR) and monocyte (MO) phagocytosis (PHAG), and oxidative-burst activity (OBA). Plasma quercetin increased from 80.0 ± 26.0 μg/L to 6,337 ± 414 μg/L immediately postexercise and 4,324 ± 310 μg/L 1 hr postexercise after ingestion of Q-chews, compared with no change in PL (p < .001). Exercise caused significant increases in, CRP, GM-CSF, IL-10, IL-1β, IL-2, IL-6, IL-8, TNFα, GR-PHAG, and MO-PHAG and decreases in GR-OBA and MO-OBA, but no differences in the pattern of change were measured between Q-chew and PL trials. Acute ingestion of Q-chews 15 min before heavy exertion caused a strong increase in plasma quercetin levels but did not counter postexercise inflammation or immune changes relative to placebo. |
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Authors:
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Manuela Konrad; David C Nieman; Dru A Henson; Krista M Kennerly; Fuxia Jin; Sandra J Wallner-Liebmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of sport nutrition and exercise metabolism Volume: 21 ISSN: 1543-2742 ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
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Languages: eng Pagination: 338-46 Citation Subset: IM |
Affiliation:
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Center for Molecular Medicine, Graz Medical University, Graz, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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