Document Detail


The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners.
MedLine Citation:
PMID:  21813917     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study tested the acute anti-inflammatory and immune-modulating influence of a quercetin-based supplement consumed by endurance athletes 15 min before an intense 2-hr run. In this randomized, crossover study, 20 runners (11 men, 9 women, age 38.4 ± 2.1 yr) completed two 2-hr treadmill runs at 70% VO2max (3 wk apart). Subjects ingested either 4 quercetin-based chews (Q-chew) or placebo chews (PL) 15 min before the runs. The 4 Q-chews provided 1,000 mg quercetin, 120 mg epigallocatechin 3-gallate, 400 mg isoquercetin, 400 mg each eicosapentaenoic acid and docosahexaenoic acid, 1,000 mg vitamin C, and 40 mg niacinamide. Subjects provided blood samples 30 min before, immediately after, and 1 hr postexercise and were analyzed for plasma quercetin, total blood leukocytes (WBC), C-reactive protein (CRP), 9 cytokines (IL-6, TNFα, GM-CSF, IFNγ, IL-1β, IL-2, IL-8, IL-10, and IL-12p70), granulocyte (GR) and monocyte (MO) phagocytosis (PHAG), and oxidative-burst activity (OBA). Plasma quercetin increased from 80.0 ± 26.0 μg/L to 6,337 ± 414 μg/L immediately postexercise and 4,324 ± 310 μg/L 1 hr postexercise after ingestion of Q-chews, compared with no change in PL (p < .001). Exercise caused significant increases in, CRP, GM-CSF, IL-10, IL-1β, IL-2, IL-6, IL-8, TNFα, GR-PHAG, and MO-PHAG and decreases in GR-OBA and MO-OBA, but no differences in the pattern of change were measured between Q-chew and PL trials. Acute ingestion of Q-chews 15 min before heavy exertion caused a strong increase in plasma quercetin levels but did not counter postexercise inflammation or immune changes relative to placebo.
Authors:
Manuela Konrad; David C Nieman; Dru A Henson; Krista M Kennerly; Fuxia Jin; Sandra J Wallner-Liebmann
Related Documents :
19469227 - Influence of different exercise regimes on the proximal hoof circumference in young tho...
19019757 - Resting concentrations of cardiac troponin i in fit horses and effect of racing.
10198377 - Interactions between gastric volume and duodenal nutrients in the control of liquid gas...
7995227 - Volume measurements of gastric antrum by 3-d ultrasonography and flow measurements thro...
21646067 - Cardio-respiratory exercise testing early after the use of the angio-seal system for ar...
11992837 - Prospective comparison of hand-assisted laparoscopic devices.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  21     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-46     Citation Subset:  IM    
Affiliation:
Center for Molecular Medicine, Graz Medical University, Graz, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of Mixed Flavonoids, n-3 Fatty Acids, and Vitamin C on Oxidative Stress and Antioxidant Capac...
Next Document:  Feeding strategies of a female athlete during an ultraendurance running event.