| The acute effect of green tea consumption on endothelial function in healthy individuals. | |
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MedLine Citation:
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PMID: 18525384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tea consumption is associated with decreased cardiovascular risk. Flow-mediated dilatation (FMD) of the brachial artery is related to coronary endothelial function and it is an independent predictor of cardiovascular risk. Black tea has a beneficial effect on endothelial function; the effect, however, of green tea on brachial artery reactivity has not been defined yet. DESIGN AND METHODS: We studied 14 healthy individuals (age 30+/-3 years) with no cardiovascular risk factors except from smoking (50%) on three separate occasions on which they took: (a) 6 g of green tea, (b) 125 mg of caffeine (the amount contained in 6 g of tea), or (c) hot water. FMD of the brachial artery was measured before each intervention and 30, 90, and 120 min afterward. High-sensitivity C-reactive protein, interleukins 6 (Il-6) and 1b (Il-1b), total plasma antioxidative capacity, and total plasma oxidative status/stress were measured at baseline and at 120 min after each intervention. RESULTS: Resting and hyperemic brachial artery diameter did not change either with tea or with caffeine. FMD increased significantly with tea (by 3.69%, peak at 30 min, P<0.02), whereas it did not change significantly with caffeine (increase by 1.72%, peak at 30 min, P=NS). Neither tea nor caffeine had any effect on high-sensitivity C-reactive protein, Il-6, Il-1b, total plasma antioxidative capacity, or total plasma oxidative status/stress. CONCLUSION: Green tea consumption has an acute beneficial effect on endothelial function, assessed with FMD of the brachial artery, in healthy individuals. This may be involved in the beneficial effect of tea on cardiovascular risk. |
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Authors:
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Nikolaos Alexopoulos; Charalambos Vlachopoulos; Konstantinos Aznaouridis; Katerina Baou; Carmen Vasiliadou; Panagiota Pietri; Panagiotis Xaplanteris; Elli Stefanadi; Christodoulos Stefanadis |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 15 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-05 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 300-5 Citation Subset: IM |
Affiliation:
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Peripheral Vessels Unit, First Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brachial Artery / drug effects* Caffeine / pharmacology* Catechin / pharmacology Central Nervous System Stimulants / pharmacology* Cross-Over Studies Drinking Endothelium, Vascular / drug effects* Female Humans Male Oxidative Stress / drug effects Single-Blind Method Tea* / chemistry Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 0/Tea; 154-23-4/Catechin; 58-08-2/Caffeine |
| Comments/Corrections | |
Comment In:
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Eur J Cardiovasc Prev Rehabil. 2008 Aug;15(4):497
[PMID:
18677179
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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