Document Detail

The acute effect of cigarette smoking on the respiratory function and FENO production among young smokers.
MedLine Citation:
PMID:  24070263     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT Introduction: Smoking is known to have a long-term impact on lung function; however, the acute physiological response of smoking a single cigarette and the influential role of pack years and cigarettes per day on pulmonary indices remains an area of interest, especially among young smokers. Methods: 50 naive smokers (ages: 18-26, 24 males: mean pack years 3.8) participated in this experimental study. Respiratory resistance (R), reactance (X ), and impedance (Z ) were assessed through impulse oscillometry. The participants' fraction of exhaled nitric oxide (FENO) was measured. All tests were performed immediately before and after smoking one single cigarette. Results: Smoking a single cigarette was found to immediately increase airway impedance (Z 5 Hz) by 0.024kPa/(L/s) (P = .002), airway resistance at R 5 Hz, R 10 Hz, and R 20 Hz by 0.024kPa/(L/s)(P < .001), 0.016kPa/(L/s)(P = .019), and 0.023kPa/(L/s) (P = .007), respectively, after adjusting for BMI, age, gender, and pack years. FENO concentrations also decreased from 11.70 ppb to 9.85 ppb, P < .001. Sensitivity analyses indicated that the participants' number of pack years and cigarettes per day influenced pulmonary reactance at 10 Hz and 20 Hz, however only at baseline with these differences found to disappear immediately after smoking. Conclusions: The present study indicates that the consumption of a single cigarette may alter lung mechanics and FENO production among young smokers. Further research is needed to assess the mechanisms and washout period after which these parameters return to normal.
Marios Kougias; Constantine I Vardavas; Nektarios Anagnostopoulos; Yuko Matsunaga; Anna Tzwrtzi; Maria Lymberi; Gregory N Connolly; Panagiotis K Behrakis
Related Documents :
23985233 - Smoker identity among occasional smokers: findings from minnesota.
16216723 - Association of ldl cholesterol with carotid atherosclerosis in menopausal women affecte...
25084213 - Testing Ødegaard's selective migration hypothesis: a longitudinal cohort study of risk...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  39     ISSN:  1521-0499     ISO Abbreviation:  Exp. Lung Res.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  359-64     Citation Subset:  IM    
1Department of Physiology, School of Medicine, University of Athens , Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The distinguishing cellular features of pulmonary artery smooth muscle cells from chronic thromboemb...
Next Document:  1,4-Cyclohexanedione. Composition, Molecular Structures, and Internal Dynamics of the Vapor: an Elec...