Document Detail

The acute and chronic effects of losartan in heart failure.
MedLine Citation:
PMID:  18800458     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Losartan is a novel, orally active, non-peptide angiotensin II receptor antagonist which specifically blocks the angiotensin II (AT1) receptor. It is postulated that losartan will have beneficial haemodynamic effects in heart failure similar to angiotensin converting enzyme inhibitors. RECENT FINDINGS: In patients with heart failure a single dose of losartan resulted in increased angiotensin II and decreased aldosterone levels. Systemic vascular resistance and systemic blood pressure were reduced. A 12-week study in similar patients found a persisting effect on systemic vascular resistance and systemic blood pressure after 12 weeks. Pulmonary capillary wedge pressure and heart rate were reduced and cardiac index increased after 12 weeks despite little acute effect on these parameters. CONCLUSIONS: Losartan resulted in favourable and persisting haemodynamic effects in patients with heart failure. Further studies will be required to fully define the role of this drug in heart failure.
I Crozier; H Ikram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  13     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1995 Jul 
Date Detail:
Created Date:  2008-09-19     Completed Date:  2008-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  S59-61     Citation Subset:  IM    
Department of Cardiology, Christchurch Hospital, New Zealand.
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MeSH Terms
Angiotensin II / blood
Angiotensin II Type 1 Receptor Blockers / pharmacology,  therapeutic use*
Blood Pressure / drug effects,  physiology
Controlled Clinical Trials as Topic
Dose-Response Relationship, Drug
Heart Failure / blood,  drug therapy*,  physiopathology
Heart Rate / drug effects,  physiology
Losartan / pharmacology,  therapeutic use*
Pulmonary Wedge Pressure / drug effects,  physiology
Renin / blood
Treatment Outcome
Vascular Resistance / drug effects,  physiology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; EC

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