| An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1{alpha} and activates mitochondrial biogenesis in human skeletal muscle. | |
| | |
MedLine Citation:
|
PMID: 21451146 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Low-volume, high-intensity interval training (HIT) increases skeletal muscle mitochondrial capacity yet little is known regarding potential mechanisms promoting this adaptive response. Our purpose was to examine molecular processes involved in mitochondrial biogenesis in human skeletal muscle in response to an acute bout of HIT. Eight healthy men performed 4 x 30-s bursts of all out maximal intensity cycling interspersed with 4 min of rest. Muscle biopsy samples (vastus lateralis) were obtained immediately before and after exercise, and after 3 and 24 h of recovery. At rest, the majority of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α, a master regulator of mitochondrial biogenesis, was detected in cytosolic fractions. Exercise activated p38 mitogen activated protein kinase (MAPK) and 5'-AMP activated protein kinase (AMPK) in the cytosol. Nuclear PGC-1α protein increased 3 h into recovery from exercise, a time point that coincided with increased mRNA expression of mitochondrial genes. This was followed by an increase in mitochondrial protein content and enzyme activity after 24 h of recovery. These findings support the hypothesis that an acute bout of low-volume HIT activates mitochondrial biogenesis through a mechanism involving increased nuclear abundance of PGC-1α. |
| | |
Authors:
|
Jonathan Peter Little; Adeel Safdar; David Bishop; Mark A Tarnopolsky; Martin J Gibala |
Related Documents
:
|
9697066 - How often do we operate too late in aortic stenosis? 8745586 - Abnormal left ventricular systolic and diastolic functional response to isometric exerc... 19944366 - Increased atrial contribution to left ventricular filling compensates for impaired earl... 11527636 - Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older ... 17885006 - Energy restriction-induced changes in body composition are age specific in mice. 6266996 - Components of alveolar-arterial o2 gradient during rest and exercise at sea level and h... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-30 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1McMaster University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bovine Rumen Epithelium Undergoes Rapid Structural Adaptations During Grain-Induced Subacute Ruminal...
Next Document: Characterization of a Novel Mouse Gene Encoding an SYCP3-Like Protein That Relocalizes from the XY B...