| The actual incidence of congenital adrenal hyperplasia in Brazil may not be as high as inferred--an estimate based on a public neonatal screening program in the state of Goiás. | |
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MedLine Citation:
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PMID: 18655527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of 21-hydroxylase deficiency (CYP21 D) congenital adrenal hyperplasia (CAH) in Brazil is purportedly one of the highest in the world (1:7,533). However, this information is not based on official data. The aim of this study was to determine the incidence of CYP21 D CAH in the state of Goiás, Brazil, based on the 2005 results of government-funded mandatory screening. Of the live births during this period, 92.95% were screened by heel-prick capillary 17alpha-hydroxyprogesterone (17-OHP). Of these, 82,343 were normal, 28 were at high risk for CAH and 232 at low risk for CAH. Eight cases, all from the high risk group, were confirmed. Eight asymptomatic children at 6-18 months of age still have high 17-OHP levels and await diagnostic definition. Based on the number of confirmed CYP21 D CAH cases among the 82,603 screened, the estimated annual incidence of the disease was 1:10,325, lower than the previously reported rate in Brazil. |
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Authors:
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Elizabeth Lemos Silveira; Eliane Pereira dos Santos; Tânia A S Bachega; Ivana van der Linden Nader; Jorge Luiz Gross; Regina Helena Elnecave |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 21 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-08-19 Revised Date: 2008-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 455-60 Citation Subset: IM |
Affiliation:
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Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxyprogesterone
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blood Adrenal Hyperplasia, Congenital / blood, diagnosis, epidemiology* Brazil / epidemiology Female Humans Incidence Infant Infant, Newborn Male Neonatal Screening / methods* Reproducibility of Results Steroid 21-Hydroxylase / genetics |
| Chemical | |
Reg. No./Substance:
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68-96-2/17-alpha-Hydroxyprogesterone; EC 1.14.99.10/Steroid 21-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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