Document Detail

The activity of tissue enzymes in iron-deficient rat and man: an overview.
MedLine Citation:
PMID:  6375945     Owner:  NLM     Status:  MEDLINE    
The effects of iron deficiency in rat and/or man on iron-containing enzymes of different tissues is reviewed. Iron deficiency results in a decrease of skeletal muscle iron containing proteins e.g. myoglobin, cytochromes c, a + a3, and alpha-glycerophosphate oxidase. Iron deficiency produces a reduction in the activity of several respiratory enzymes in the mitochondrial fraction of cardiac muscle, particularly: NADH cytochrome c reductase, succinic cytochrome c reductase, succinic dehydrogenase and NADH ferricyanide oxidoreductase. The effects of iron deficiency on brain tissue is emphasized with respect to cytochromes, monoaminoxidase and amino acids metabolism. Host defence to infection (controversial data), decrease in body temperature, alteration of DNA synthesis, collagen and lipid metabolism, liver and gastrointestinal mucous cytochromes activity perturbations are discussed.
P Galan; S Hercberg; Y Touitou
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  77     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1984  
Date Detail:
Created Date:  1984-07-30     Completed Date:  1984-07-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  647-53     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism
Body Temperature
Brain / enzymology*
Collagen / biosynthesis
Cytochromes / metabolism
DNA / biosynthesis
Gastric Mucosa / enzymology
Immunity, Innate
Infection / immunology
Intestinal Mucosa / enzymology
Iron / deficiency*
Lipid Metabolism
Liver / enzymology*
Monoamine Oxidase / metabolism
Muscles / enzymology*
Myocardium / enzymology*
Reg. No./Substance:
0/Amino Acids; 0/Cytochromes; 7439-89-6/Iron; 9007-34-5/Collagen; 9007-49-2/DNA; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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