Document Detail


The activity of cerebellar neurones of the decerebrate dogfish Scyliorhinus during spontaneous swimming movements.
MedLine Citation:
PMID:  6747883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patterns of activity of cerebellar neurones in response to cutaneous stimulation and during spontaneous, swimming-like movements were examined, using microelectrodes, in decerebrate dogfish (Scyliorhinus canicula). Continuous swimming movements, lasting for several hours, were obtained in fish in which the medial longitudinal fasciculus (m.l.f.) was lesioned in the rhombencephalon. Purkinje cells (P cells) and some stellate cells (S cells) were observed to discharge rhythmically, in phase with swimming movements. These units were distributed throughout the cerebellum, but with no apparent somatotopic distribution. After curarization, rhythmic motor discharges could still be recorded from ventral roots and phase locked P cell discharges were recorded from the cerebellum. P cells that discharged rhythmically during active swimming movements, did not do so when the body was oscillated passively during quiescent periods. Cutaneous stimulation evoked burst discharges in many P cells at long latency (ca. 100 ms) both before and after curarization and whether or not a rhythmic motor output was being generated. In rhythmically discharging units, a similar response was obtained when cutaneous stimulation was applied during that part of a cycle when the unit was most or least active. It was concluded that cerebellar neurones discharged in phase with the output of the spinal locomotory rhythm generators and independently of peripheral sensory feed-back.
Authors:
D H Paul; B L Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  352     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-19     Completed Date:  1984-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Cerebellum / cytology,  physiology*
Curare / pharmacology
Decerebrate State*
Dogfish / physiology*
Mesencephalon / physiology
Movement* / drug effects
Neural Pathways / physiology
Neurons / physiology*
Purkinje Cells / physiology
Sharks / physiology*
Spinal Cord / physiology
Time Factors
Chemical
Reg. No./Substance:
8063-06-7/Curare
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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